CAS 8050-81-5 Simethicone - Analytical Products / Alfa Chemistry

CAT	AP8050815
CAS	8050-81-5
Structure

Description	United States Pharmacopeia (USP) Reference Standard
Form	neat
Size	50G

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Case Study

Simethicone Is Used for Nanopipette Surface Modification to Achieve Sub-10 nm Resolution in SECCM Imaging

Liu, Gen, et al. Sensors and Actuators B: Chemical 409 (2024): 135603.

Simethicone has been demonstrated as an effective surface-modifying agent in the fabrication of high-resolution scanning electrochemical cell microscopy (SECCM) probes. In a recent study, a single-barrel borosilicate nanopipette with a tip diameter of ~129 nm was coated with a thin simethicone oil film to reduce the effective area of the exposed electrolyte meniscus. This simple yet innovative tip-oil coating technique allowed the generation of electrochemical images with pixel sizes below 10 nm-surpassing the conventional resolution limitations imposed by pipette size in hopping-mode SECCM.
The coating process involved gently contacting the nanopipette tip with the simethicone surface under controlled speed to prevent breakage, followed by brief holding and withdrawal to form a stable, thin oil film. The simethicone film introduced surface tension effects that minimized the contact area between the electrolyte and sample surface. This physical barrier enhanced spatial confinement and reduced pixel overlap, enabling unprecedented electrochemical and topographical resolution.
This modification strategy was successfully applied in both neutral and extreme pH conditions using redox-active species such as Fe(CN)₆³⁻. The results clearly show that simethicone enables large-diameter probes to perform high-resolution SECCM imaging, making it a valuable tool for nanoscale electrochemical characterization. Thus, simethicone plays a critical role in expanding the capabilities and versatility of SECCM across various research domains.

Simethicone Is Used for the Generation and Quantification of Airborne Molecular Contaminants (AMCs) in Cleanroom Environments

Zhou, Guorui, et al. Sensors and Actuators A: Physical 287 (2019): 1-7.

Simethicone, a widely used lubricant and sealing agent in high-precision laboratories (HPLs), has been employed as a model compound for the controlled generation of airborne molecular contaminants (AMCs) in cleanroom studies. In a recent investigation, simethicone was selected to simulate AMC behavior under thermally induced outgassing conditions. The experiment was conducted in an ISO 5 cleanroom using a tightly sealed chamber to minimize background interference.
Simethicone was heated to various temperatures (30-70 °C) using a precision-controlled magnetic stirrer to induce volatilization. The evolved AMCs were quantified by mass loss, determined through repeated microbalance measurements. Simultaneously, a fabricated optical microcavity (OMC) sensor was exposed to the released AMCs, and its transmission spectra were monitored in real time.
The results revealed that the dip wavelength of the OMC sensor exhibited a consistent blue shift proportional to the AMC concentration, with shifts ranging from 7.2 nm to 73 nm as AMC concentrations increased from 25.71 mg/m³ to 134.2 mg/m³. A non-linear, polynomial relationship between AMC concentration and wavelength shift was observed. Notably, the sensor exhibited increasing sensitivity at higher contaminant concentrations, reaching a maximum sensitivity of 0.541 nm/(mg/m³).
This study highlights the utility of simethicone as a benchmark contaminant for evaluating AMC sensor performance and cleanroom air quality. Its predictable volatilization behavior and compatibility with optical sensing platforms make it a valuable tool in the development of advanced AMC detection technologies.

Simethicone Used for Refractive Index Measurement via Liquid Prism SPR Sensor

Lan, Guoqiang, Yachen Gao, and Xueru Zhang. Sensing and bio-sensing research 16 (2017): 32-36.

Simethicone, a widely known antifoaming agent, has demonstrated its utility beyond pharmaceutical applications in recent experimental studies utilizing surface plasmon resonance (SPR) sensors. In a recent investigation, a liquid prism SPR sensor integrating both angular and spectral interrogation was employed to measure the chromatic dispersion and refractive index of various liquid samples, including simethicone.
The study compared the performance of gold (Au) and silver (Ag) thin films as plasmonic layers, with simethicone among six test liquids evaluated. The SPR response of simethicone was obtained by analyzing the resonance angle shifts across different wavelengths. Results showed that the refractive indices determined by SPR closely matched those obtained using a standard Abbe refractometer at 532 nm, 589 nm, and 635 nm, demonstrating excellent consistency and validating the sensor's accuracy. Notably, the Ag-based SPR configuration exhibited a broader spectral range, enhancing sensitivity in the visible region.
Simethicone's stable optical behavior and consistent refractive index made it a suitable reference material in the development and validation of advanced optical sensing systems. This case highlights the versatility of simethicone in precision optical applications, particularly in chromatic dispersion measurement using SPR techniques. The method presents a promising approach for the quasi-continuous measurement of liquid dispersion characteristics over a wide spectral range, expanding the analytical potential of simethicone in scientific instrumentation and material characterization.