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SJ-172550

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For Research Use Only | Not For Clinical Use
CATAP431979474
CAS431979-47-4
Structure
MDL NumberMFCD03142926
Molecular Weight428.87
InChI KeyRKKFQJXGAQWHBZ-YVLHZVERSA-N
Description≥95% (HPLC)
SolubilityDMSO: ≥30 mg/mL
Assay≥95% (HPLC)
Colororange
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

Chemical Instability and Promiscuity of Arylmethylidenepyrazolinone-Based MDMX Inhibitors

Jakub Stefaniak, Andrew M Lewis, Daniel Conole, Sébastien R G Galan, Carole J R Bataille, Graham M Wynne, M Paola Castaldi, Thomas Lundbäck, Angela J Russell, Kilian V M Huber

ACS Chem Biol. 2018 Oct 19;13(10):2849-2854.

PMID: 30216042

1

Identification and Characterization of the First Small Molecule Inhibitor of MDMX

Damon Reed, Ying Shen, Anang A Shelat, Leggy A Arnold, Antonio M Ferreira, Fangyi Zhu, Nicholas Mills, David C Smithson, Catherine A Regni, Donald Bashford, Samantha A Cicero, Brenda A Schulman, Aart G Jochemsen, etc.

J Biol Chem. 2010 Apr 2;285(14):10786-96.

PMID: 20080970

1

Medicinal Chemistry Strategies to Disrupt the p53-MDM2/MDMX Interaction

Agostinho Lemos, Mariana Leão, Joana Soares, Andreia Palmeira, Madalena Pinto, Lucília Saraiva, Maria Emília Sousa

Med Res Rev. 2016 Sep;36(5):789-844.

PMID: 27302609

1

Novel Simplified Yeast-Based Assays of Regulators of p53-MDMX Interaction and p53 Transcriptional Activity

Mariana Leão, Sara Gomes, Joana Soares, Cláudia Bessa, Cláudia Maciel, Yari Ciribilli, Clara Pereira, Alberto Inga, Lucília Saraiva

FEBS J. 2013 Dec;280(24):6498-507.

PMID: 24119020

1

On the Mechanism of Action of SJ-172550 in Inhibiting the Interaction of MDM4 and p53

Michal Bista, David Smithson, Aleksandra Pecak, Gabriella Salinas, Katarzyna Pustelny, Jaeki Min, Artur Pirog, Kristin Finch, Michal Zdzalik, Brett Waddell, Benedykt Wladyka, Sylwia Kedracka-Krok, Michael A Dyer, etc.

PLoS One. 2012;7(6):e37518.

PMID: 22675482

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