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SL327

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For Research Use Only | Not For Clinical Use
CATAP305350872
CAS305350-87-2
Structure
MDL NumberMFCD06411432
Molecular Weight335.35
InChI KeyJLOXTZFYJNCPIS-FYWRMAATSA-N
Description≥98% (HPLC), Mixture of E & Z isomers, solid
SolubilityDMSO: >10 mg/mL; H2O: insoluble
Assay≥98% (HPLC)
Colorwhite to off-white
Formsolid; protect from light
MP127-128.2 °C
Size5MG, 25MG
Storage Conditions2-8°C
1

Combination of SL327 and Sunitinib Malate Leads to an Additive Anti-Cancer Effect in Doxorubicin Resistant Thyroid Carcinoma Cells

Wei Wang, Jin Zhou, Lujie Zhao, Shulin Chen

Biomed Pharmacother. 2017 Apr;88:985-990.

PMID: 28178630

1

Differential Effects of MEK Inhibitors on Rat Neural Stem Cell Differentiation: Repressive Roles of MEK2 in Neurogenesis and Induction of Astrocytogenesis by PD98059

Ha-Rim Lee, Jeewoo Lee, Hyun-Jung Kim

Pharmacol Res. 2019 Nov;149:104466.

PMID: 31562895

1

Differential Effects of the MEK Inhibitor SL327 on the Acquisition and Expression of Ethanol-Elicited Conditioned Place Preference and Aversion in Mice

Michela Rosas, Simona Porru, Rosanna Longoni, Liliana Spina, Alessandra T Peana, Maria Collu, Elio Acquas

J Psychopharmacol. 2017 Jan;31(1):105-114.

PMID: 28072036

1

Inhibition of Extracellular Signal-Regulated Kinase (ERK) Activity With SL327 Does Not Prevent Acquisition, Expression, and Extinction of Ethanol-Seeking Behavior in Mice

Peter A Groblewski, Frederick H Franken, Christopher L Cunningham

Behav Brain Res. 2011 Mar 1;217(2):399-407.

PMID: 21074569

1

The MEK Inhibitor SL327 Blocks Acquisition but Not Expression of Lithium-Induced Conditioned Place Aversion: A Behavioral and Immunohistochemical Study

Rosanna Longoni, Liliana Spina, Stefania Vinci, Elio Acquas

Psychopharmacology (Berl). 2011 Jul;216(1):63-73.

PMID: 21312031

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