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SMI-4a

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For Research Use Only | Not For Clinical Use
CATAP438190295
CAS438190-29-5
Structure
MDL NumberMFCD01152003
Molecular Weight273.23
InChI KeyNGJLOFCOEOHFKQ-YVMONPNESA-N
Description≥98% (HPLC)
SolubilityDMSO: >10 mg/mL
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size10MG
Storage Conditions2-8°C
1

Ginsenoside G-Rh2 Synergizes With SMI-4a in Anti-Melanoma Activity Through Autophagic Cell Death

Da-Lun Lv, Lei Chen, Wei Ding, Wei Zhang, He-Li Wang, Shuai Wang, Wen-Bei Liu

Chin Med. 2018 Feb 21;13:11.

PMID: 29483938

1

PIM Inhibitor SMI-4a Induces Cell Apoptosis in B-cell Acute Lymphocytic Leukemia Cells via the HO-1-mediated JAK2/STAT3 Pathway

Xingyi Kuang, Jie Xiong, Weili Wang, Xinyao Li, Tingting Lu, Qin Fang, Jishi Wang

Life Sci. 2019 Feb 15;219:248-256.

PMID: 30658101

1

PIM1 Inhibitor SMI-4a Attenuated Lipopolysaccharide-Induced Acute Lung Injury Through Suppressing Macrophage Inflammatory Responses via Modulating p65 Phosphorylation

Jinxuan Wang, Yumeng Cao, Yuqi Liu, Xinyi Zhang, Fanceng Ji, Jinbao Li, Yun Zou

Int Immunopharmacol. 2019 Aug;73:568-574.

PMID: 31203114

1

Pim-1 Inhibitor SMI-4a Suppresses Tumor Growth in Non-Small Cell Lung Cancer via PI3K/AKT/mTOR Pathway

Wenjie Jiang, Yuan Chen, Xing Song, Yingjie Shao, Zhonghua Ning, Wendong Gu

Onco Targets Ther. 2019 Apr 23;12:3043-3050.

PMID: 31114247

1

PIM-1 Kinase Inhibitor SMI-4a Exerts Antitumor Effects in Chronic Myeloid Leukemia Cells by Enhancing the Activity of Glycogen Synthase Kinase 3β

Rui-Fang Fan, Ying Lu, Zhi-Gang Fang, Xiao-Yan Guo, Yu-Xin Chen, Yi-Chuan Xu, Ya-Mei Lei, Ke-Fang Liu, Dong-Jun Lin, Ling-Ling Liu, Xiang-Fu Liu

Mol Med Rep. 2017 Oct;16(4):4603-4612.

PMID: 28849186

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