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Smoothened Agonist, SAG - CAS 364590-63-6

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For Research Use Only | Not For Clinical Use
CATAP364590636
CAS364590-63-6
Molecular Weight490.06
DescriptionA cell-permeable Smoothened Agonist, SAG, CAS 364590-63-6, modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM).
SolubilityDMSO: 10 mg/mL; water: 25 mg/mL
Assay≥98% (HPLC)
Colorlight yellow
Formsolid; desiccated; protect from light
Size1MG, 5MG
Storage Conditions+2C to +8C
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Inhibition of Smoothened in Breast Cancer Cells Reduces CAXII Expression and Cell Migration

Giuditta Guerrini, Mattia Criscuoli, Irene Filippi, Antonella Naldini, Fabio Carraro

J Cell Physiol. 2018 Dec;233(12):9799-9811.

PMID: 30132883

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