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SP600125

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For Research Use Only | Not For Clinical Use
CATIAR4245027
MDL NumberMFCD00022289
Molecular Weight220.23
EC Number204-955-6
InChI KeyACPOUJIDANTYHO-UHFFFAOYSA-N
Description≥98% (HPLC)
SolubilityDMSO: 20 mg/ml, clear to very slightly hazy, faintly yellow to yellow; H2O: insoluble
Assay≥98% (HPLC)
Coloryellow
Size10MG, 50MG
Storage Conditions2-8°C
1

Effect of SP600125 on the Mitotic Spindle in HeLa Cells, Leading to Mitotic Arrest, Endoreduplication and Apoptosis

Donia Mili, Kaouthar Abid, Imed Rjiba, Abderraouf Kenani

Mol Cytogenet. 2016 Nov 25;9:86.

PMID: 27924151

1

SP600125 Enhances C-2-induced Cell Death by the Switch From Autophagy to Apoptosis in Bladder Cancer Cells

Haiyang Yu, Chun-Li Wu, Xiangyu Wang, Qianhong Ban, Chunhua Quan, Mengbo Liu, Hangqi Dong, Jinfeng Li, Gi-Young Kim, Yung Hyun Choi, Zhenya Wang, Cheng-Yun Jin

J Exp Clin Cancer Res. 2019 Nov 4;38(1):448.

PMID: 31685029

1

SP600125 suppresses Keap1 expression and results in NRF2-mediated prevention of diabetic nephropathy

Huan Zhang, Xiuxia Liu, Shanshan Zhou, Ye Jia, Ying Li, Yuguo Song, Junnan Wang, Hao Wu

J Mol Endocrinol. 2018 Feb;60(2):145-157.

PMID: 29273684

1

Trimethylamine N-oxide Promotes Atherosclerosis via CD36-dependent MAPK/JNK Pathway

Jin Geng, Chenchen Yang, Bingjian Wang, Xiwen Zhang, Tingting Hu, Yang Gu, Ju Li

Biomed Pharmacother. 2018 Jan;97:941-947.

PMID: 29136772

1

Use of Saikosaponin D and JNK Inhibitor SP600125, Alone or in Combination, Inhibits Malignant Properties of Human Osteosarcoma U2 Cells

Tian Gao, Ping Zhao, Xiaolong Yu, Suixia Cao, Bin Zhang, Min Dai

Am J Transl Res. 2019 Apr 15;11(4):2070-2080.

PMID: 31105818

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