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SPD304

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For Research Use Only | Not For Clinical Use
CATIAR4244986
MDL NumberMFCD09265259
Molecular Weight620.53
InChI KeyGOZMBJCYMQQACI-UHFFFAOYSA-N
Description≥98% (HPLC), solid
SolubilityH2O: >5 mg/mL
Assay≥98% (HPLC)
Colorwhite
Formsolid
Size1MG, 5MG
Storage Conditions2-8°C
1

Aqueous Solubility Enhancement for Bioassays of Insoluble Inhibitors and QSPR Analysis: A TNF-α Study

Anthi Mettou, Christos Papaneophytou, Georgia Melagraki, Anna Maranti, Fotini Liepouri, Polyxeni Alexiou, Athanasios Papakyriakou, Elias Couladouros, Elias Eliopoulos, Antreas Afantitis, George Kontopidis

SLAS Discov. 2018 Jan;23(1):84-93.

PMID: 28586633

1

Brain TACE (Tumor Necrosis Factor-α-Converting Enzyme) Contributes to Sympathetic Excitation in Heart Failure Rats

Yang Yu, Yiling Cao, Balyssa Bell, Xiaolei Chen, Robert M Weiss, Robert B Felder, Shun-Guang Wei

Hypertension. 2019 Jul;74(1):63-72.

PMID: 31154904

1

Cheminformatics-aided Discovery of Small-Molecule Protein-Protein Interaction (PPI) Dual Inhibitors of Tumor Necrosis Factor (TNF) and Receptor Activator of NF-κB Ligand (RANKL)

Georgia Melagraki, Evangelos Ntougkos, Vagelis Rinotas, Christos Papaneophytou, Georgios Leonis, Thomas Mavromoustakos, George Kontopidis, Eleni Douni, Antreas Afantitis, George Kollias

PLoS Comput Biol. 2017 Apr 20;13(4):e1005372.

PMID: 28426652

1

Fullerenes and Their Derivatives as Inhibitors of Tumor Necrosis factor-α With Highly Promoted Affinities

Gaoyin Wu, Xuejiao J Gao, Joonkyung Jang, Xingfa Gao

J Mol Model. 2016 Jul;22(7):161.

PMID: 27316702

1

Solvent Selection for Insoluble Ligands, a Challenge for Biological Assay Development: A TNF-α/SPD304 Study

Christos P Papaneophytou, Anthi K Mettou, Vagelis Rinotas, Eleni Douni, George A Kontopidis

ACS Med Chem Lett. 2012 Nov 29;4(1):137-41.

PMID: 24900576

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