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Spermidine

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For Research Use Only | Not For Clinical Use
CATAP124209
CAS124-20-9
Structure
MDL NumberMFCD00008229
Molecular Weight145.25
EC Number204-689-0
InChI KeyATHGHQPFGPMSJY-UHFFFAOYSA-N
REAXYS Number1698591
Descriptionanalytical standard
Density0.925 g/mL at 25 °C (lit.)
Assay≥97.5% (NT); ≥99.0% (GC)
Formneat; gas chromatography (GC): suitable
Gradeanalytical standard
Linear FormulaNH2(CH2)3NH(CH2)4NH2
Refractive Indexn20/D 1.479 (lit.)
Size100MG
Storage Conditions2-8°C
1

Cardioprotection and Lifespan Extension by the Natural Polyamine Spermidine

Tobias Eisenberg, Mahmoud Abdellatif, Sabrina Schroeder, Uwe Primessnig, Slaven Stekovic, Tobias Pendl, Alexandra Harger, Julia Schipke, Andreas Zimmermann, Albrecht Schmidt, Mingming Tong, Christoph Ruckenstuhl, etc.

Nat Med. 2016 Dec;22(12):1428-1438.

PMID: 27841876

1

Dietary Spermidine for Lowering High Blood Pressure

Tobias Eisenberg, Mahmoud Abdellatif, Andreas Zimmermann, Sabrina Schroeder, Tobias Pendl, Alexandra Harger, Slaven Stekovic, Julia Schipke, Christoph Magnes, Albrecht Schmidt, Christoph Ruckenstuhl, Christopher Dammbrueck, etc.

Autophagy. 2017 Apr 3;13(4):767-769.

PMID: 28118075

1

Safety and Tolerability of Spermidine Supplementation in Mice and Older Adults With Subjective Cognitive Decline

Claudia Schwarz, Slaven Stekovic, Miranka Wirth, Gloria Benson, Philipp Royer, Stephan J Sigrist, Thomas Pieber, Christopher Dammbrueck, Christoph Magnes, Tobias Eisenberg, Tobias Pendl, Jens Bohlken, Theresa Köbe, etc.

Aging (Albany NY). 2018 Jan 8;10(1):19-33.

PMID: 29315079

1

Spermidine: A Physiological Autophagy Inducer Acting as an Anti-Aging Vitamin in Humans?

Frank Madeo, Maria A Bauer, Didac Carmona-Gutierrez, Guido Kroemer

Autophagy. 2019 Jan;15(1):165-168.

PMID: 30306826

1

Spermidine-enhanced Autophagic Flux Improves Cardiac Dysfunction Following Myocardial Infarction by Targeting the AMPK/mTOR Signalling Pathway

Jing Yan, Jian-Yun Yan, Yu-Xi Wang, Yuan-Na Ling, Xu-Dong Song, Si-Yi Wang, Hai-Qiong Liu, Qi-Cai Liu, Ya Zhang, Ping-Zhen Yang, Xian-Bao Wang, Ai-Hua Chen

Br J Pharmacol. 2019 Sep;176(17):3126-3142.

PMID: 31077347

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