sPLA₂-IIA Inhibitor I - Analytical Products / Alfa Chemistry

CAT	IAR4247119
Molecular Weight	750.89 (free base basis)

Description	The sPLA₂-IIA Inhibitor I controls the biological activity of sPLA₂-IIA. This small molecule/inhibitor is primarily used for Cell Signaling applications.
Solubility	DMSO: 5 mg/mL
Assay	≥95% (HPLC)
Color	white
Form	lyophilized solid; desiccated
Size	1MG
Storage Conditions	-20C

1

A Concise Update on the Relevance of Secretory Phospholipase A2 Group IIA and Its Inhibitors With Cancer

Juan Chen, Long Ye, Yu Sun, Yoshikazhu Takada

Med Chem. 2017;13(7):606-615.

PMID: 28185537

1

Inhibition of Secretory Phospholipase A2 IIa Attenuates Prostaglandin E2-induced Invasiveness in Lung Adenocarcinoma

Alison L Halpern, Patrick D Kohtz, Jessica Y Rove, Lihua Ao, Xianzhong Meng, David A Fullerton, Michael J Weyant

Mol Cell Biochem. 2019 Jun;456(1-2):145-156.

PMID: 30684134

1

Inhibition of sPLA₂-IIA Prevents LPS-induced Neuroinflammation by Suppressing ERK1/2-cPLA₂α Pathway in Mice Cerebral Cortex

Yanxiao Xiang, Lin Chen, Huiqing Liu, Xiaoqian Liu, Xinbing Wei, Baozhu Sun, Tian Wang, Xiumei Zhang

PLoS One. 2013 Oct 9;8(10):e77909.

PMID: 24130900

1

Maslinic Acid Modulates Secreted Phospholipase A2-IIA (sPLA2-IIA)-mediated Inflammatory Effects in Macrophage Foam Cells Formation

Wei Hsum Yap, Bee Kee Ooi, Nafees Ahmed, Yang Mooi Lim

J Biosci. 2018 Jun;43(2):277-285.

PMID: 29872016

1

Regulatory Effects of the JAK3/STAT1 Pathway on the Release of Secreted Phospholipase A₂-IIA in Microvascular Endothelial Cells of the Injured Brain

Guansong Wang, Pin Qian, Zhi Xu, Jiqiang Zhang, Yaoli Wang, Saiyu Cheng, Wenqin Cai, Guisheng Qian, Changzheng Wang, Mark A Decoster

J Neuroinflammation. 2012 Jul 12;9:170.

PMID: 22788969