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STA-21

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For Research Use Only | Not For Clinical Use
CATAP111540002
CAS111540-00-2
MDL NumberMFCD16883374
Molecular Weight306.31
Description≥95% (HPLC)
SolubilityDMSO: 2 mg/mL, clear
Assay≥95% (HPLC)
Coloryellow to brown
Formpowder
Size1MG, 5MG
Storage Conditions−20°C
1

Development of Oxadiazole-Based ODZ10117 as a Small-Molecule Inhibitor of STAT3 for Targeted Cancer Therapy

Byung-Hak Kim, Haeri Lee, Yeonghun Song, Joon-Suk Park, Changdev G Gadhe, Jiwon Choi, Chung-Gi Lee, Ae Nim Pae, Sanghee Kim, Sang-Kyu Ye

J Clin Med. 2019 Nov 2;8(11):1847.

PMID: 31684051

1

STA-21, a Promising STAT-3 Inhibitor That Reciprocally Regulates Th17 and Treg Cells, Inhibits Osteoclastogenesis in Mice and Humans and Alleviates Autoimmune Inflammation in an Experimental Model of Rheumatoid Arthritis

Jin-Sil Park, Seung-Ki Kwok, Mi-Ae Lim, Eun-Kyung Kim, Jun-Geol Ryu, Sung-Min Kim, Hye-Joa Oh, Ji Hyeon Ju, Sung-Hwan Park, Ho-Youn Kim, Mi-La Cho

Arthritis Rheumatol. 2014 Apr;66(4):918-29.

PMID: 24757144

1

STA-21, a STAT-3 Inhibitor, Attenuates the Development and Progression of Inflammation in Collagen Antibody-Induced Arthritis

Sheikh Fayaz Ahmad, Mushtaq Ahmad Ansari, Ahmed Nadeem, Khairy M A Zoheir, Saleh A Bakheet, Abdulaziz M S Alsaad, Othman A Al-Shabanah, Sabry M Attia

Immunobiology. 2017 Feb;222(2):206-217.

PMID: 27717524

1

Stat3 as a Therapeutic Target for the Treatment of Psoriasis: A Clinical Feasibility Study With STA-21, a Stat3 Inhibitor

Ken Miyoshi, Mikiro Takaishi, Kimiko Nakajima, Mitsunori Ikeda, Takashi Kanda, Masahito Tarutani, Tatsuo Iiyama, Naoki Asao, John DiGiovanni, Shigetoshi Sano

J Invest Dermatol. 2011 Jan;131(1):108-17.

PMID: 20811392

1

STAT3 Regulates the Onset of Oxidant-induced Senescence in Lung Fibroblasts

David W Waters, Kaj E C Blokland, Prabuddha S Pathinayake, Lan Wei, Michael Schuliga, Jade Jaffar, Glen P Westall, Philip M Hansbro, Cecilia M Prele, Steven E Mutsaers, Nathan W Bartlett, Janette K Burgess, etc.

Am J Respir Cell Mol Biol. 2019 Jul;61(1):61-73.

PMID: 30608861

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