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SU1498

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For Research Use Only | Not For Clinical Use
CATIAR42415698
Molecular Weight390.52
DescriptionA potent, reversible, ATP-competitive and selective inhibitor of Flk-1 kinase (IC₅₀ = 700 nM), a vascular endothelial growth factor (VEGF) receptor kinase.
SolubilityDMSO: 5 mg/mL
Assay≥95% (HPLC)
Colorpale yellow
Formsolid; protect from light
Size5MG
Storage Conditions-20C
1

ADAMTS13 Controls Vascular Remodeling by Modifying VWF Reactivity During Stroke Recovery

Haochen Xu, Yongliang Cao, Xing Yang, Ping Cai, Lijing Kang, Ximin Zhu, Haiyu Luo, Lu Lu, Lixiang Wei, Xiaofei Bai, Yuanbo Zhu, Bing-Qiao Zhao, Wenying Fan

Blood. 2017 Jul 6;130(1):11-22.

PMID: 28428179

1

CXCL12 Promotes Human Ovarian Cancer Cell Invasion Through Suppressing ARHGAP10 Expression

Ning Luo, Dan-Dan Chen, Li Liu, Li Li, Zhong-Ping Cheng

Biochem Biophys Res Commun. 2019 Oct 20;518(3):416-422.

PMID: 31445707

1

High-density Lipoprotein (HDL) Promotes Angiogenesis via S1P3-dependent VEGFR2 Activation

Fengyan Jin, Nina Hagemann, Li Sun, Jiang Wu, Thorsten R Doeppner, Yun Dai, Dirk M Hermann

Angiogenesis. 2018 May;21(2):381-394.

PMID: 29450744

1

Lack of Effect of SU1498, an Inhibitor of Vascular Endothelial Growth Factor receptor-2, in a Transgenic Murine Model of Retinoblastoma

C M Cebulla, M E Jockovich, H Boutrid, Y Piña, M Ruggeri, S Jiao, S K Bhattacharya, W J Feuer, T G Murray

Open Ophthalmol J. 2008 Apr 2;2:62-7.

PMID: 19517030

1

SU1498, an Inhibitor of Vascular Endothelial Growth Factor Receptor 2, Causes Accumulation of Phosphorylated ERK Kinases and Inhibits Their Activity in Vivo and in Vitro

George Boguslawski, Patrick W McGlynn, Kevin A Harvey, A Thomas Kovala

J Biol Chem. 2004 Feb 13;279(7):5716-24.

PMID: 14625306

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