CAS 138154-39-9 Symadex - Analytical Products / Alfa Chemistry

CAT	AP138154399
CAS	138154-39-9
Structure
MDL Number	MFCD00947296
Molecular Weight	350.41
InChI Key	CUNDRHORZHFPLY-UHFFFAOYSA-N

Description	≥98% (HPLC)
Solubility	DMSO: 10 mg/mL (clear solution; warmed)
Assay	≥98% (HPLC)
Color	white to beige
Form	powder
Size	5MG, 25MG
Storage Conditions	2-8°C

1

Antitumour Imidazoacridone C-1311 Induces Cell Death by Mitotic Catastrophe in Human Colon Carcinoma Cells

Magdalena Hyzy, Przemyslaw Bozko, Jerzy Konopa, Andrzej Skladanowski

Biochem Pharmacol. 2005 Mar 1;69(5):801-9.

PMID: 15710357

1

Comparative Cytotoxicity of C-1311 in Colon Cancer in Vitro and in Vivo Using the Hollow Fiber Assay

N Alami, J Paterson, S Belanger, S Juste, C K Grieshaber, B Leyland-Jones

J Chemother. 2007 Oct;19(5):546-53.

PMID: 18073154

1

Evaluation of the Safety of C-1311 (SYMADEX) Administered in a Phase 1 Dose Escalation Trial as a Weekly Infusion for 3 Consecutive Weeks in Patients With Advanced Solid Tumours

N Isambert, M Campone, E Bourbouloux, M Drouin, A Major, W Yin, P Loadman, R Capizzi, C Grieshaber, P Fumoleau

Eur J Cancer. 2010 Mar;46(4):729-34.

PMID: 20031390

1

Structural Determinants of Imidazoacridinones Facilitating Antitumor Activity Are Crucial for Substrate Recognition by ABCG2

Eran E Bram, Yamit Adar, Nufar Mesika, Michal Sabisz, Andrzej Skladanowski, Yehuda G Assaraf

Mol Pharmacol. 2009 May;75(5):1149-59.

PMID: 19251825

1

The Imidazoacridinone C-1311 Induces p53-dependent Senescence or p53-independent Apoptosis and Sensitizes Cancer Cells to Radiation

Anna Skwarska, Shaliny Ramachandran, Grzegorz Dobrynin, Katarzyna B Leszczynska, Ester M Hammond

Oncotarget. 2017 May 9;8(19):31187-31198.

PMID: 28415717

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