CAS 189060-13-7 TAK-475 - Analytical Products / Alfa Chemistry

1

Drug Evaluation: TAK-475--an Oral Inhibitor of Squalene Synthase for Hyperlipidemia

John R Burnett

Curr Opin Investig Drugs. 2006 Sep;7(9):850-6.

PMID: 17002264

1

Lipid-lowering Effects of TAK-475, a Squalene Synthase Inhibitor, in Animal Models of Familial Hypercholesterolemia

Yuichiro Amano, Tomoyuki Nishimoto, Ryu ichi Tozawa, Eiichiro Ishikawa, Yoshimi Imura, Yasuo Sugiyama

Eur J Pharmacol. 2003 Apr 11;466(1-2):155-61.

PMID: 12679152

1

Lipid-lowering Properties of TAK-475, a Squalene Synthase Inhibitor, in Vivo and in Vitro

Tomoyuki Nishimoto, Yuichiro Amano, Ryuichi Tozawa, Eiichiro Ishikawa, Yoshimi Imura, Hidefumi Yukimasa, Yasuo Sugiyama

Br J Pharmacol. 2003 Jul;139(5):911-8.

PMID: 12839864

1

Pharmacokinetics of TAK-475, a Squalene Synthase Inhibitor, in Rats and Dogs

T Ebihara, K Teshima, T Kondo, Y Tagawa, T Moriwaki, S Asahi

Drug Res (Stuttg). 2016 Jun;66(6):287-92.

PMID: 26839207

1

Repositioning of Tak-475 In Mevalonate Kinase Disease: Translating Theory Into Practice

Annalisa Marcuzzi, Claudia Loganes, Claudio Celeghini, Giulio Kleiner

Curr Med Chem. 2018;25(24):2783-2796.

PMID: 28901277