CAS 303162-79-0 TAK-715 - Analytical Products / Alfa Chemistry

CAT	AP303162790
CAS	303162-79-0
MDL Number	MFCD17012805
Molecular Weight	399.51
InChI Key	HEKAIDKUDLCBRU-UHFFFAOYSA-N

Description	≥98% (HPLC)
Solubility	DMSO: >15 mg/mL
Assay	≥98% (HPLC)
Color	faintly yellow to dark yellow
Form	powder
Size	5MG, 25MG
Storage Conditions	2-8°C

1

Inhibition of Wnt/β-catenin Signaling by p38 MAP Kinase Inhibitors Is Explained by Cross-Reactivity With Casein Kinase Iδ/ɛ

Folkert Verkaar, Antoon A van der Doelen, Jos F M Smits, W Matthijs Blankesteijn, Guido J R Zaman

Chem Biol. 2011 Apr 22;18(4):485-94.

PMID: 21513885

1

Novel Inhibitor of p38 MAP Kinase as an anti-TNF-alpha Drug: Discovery of N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (TAK-715) as a Potent and Orally Active Anti-Rheumatoid Arthritis Agent

Seiji Miwatashi, Yasuyoshi Arikawa, Etsuo Kotani, Maki Miyamoto, Ken-Ichi Naruo, Hiroyuki Kimura, Toshimasa Tanaka, Satoru Asahi, Shigenori Ohkawa

J Med Chem. 2005 Sep 22;48(19):5966-79.

PMID: 16162000

1

Structure-based Design, Synthesis, and Biological Evaluation of imidazo[1,2-b]pyridazine-based p38 MAP Kinase Inhibitors

Akira Kaieda, Masashi Takahashi, Takafumi Takai, Masayuki Goto, Takahiro Miyazaki, Yuri Hori, Satoko Unno, Tomohiro Kawamoto, Toshimasa Tanaka, Sachiko Itono, Terufumi Takagi, Teruki Hamada, Mikio Shirasaki, etc.

Bioorg Med Chem. 2018 Feb 1;26(3):647-660.

PMID: 29291937

1

Tandem Mass Spectrometry Study of p38α Kinase Inhibitors and Related Substances

D Falck, J Kool, M Honing, W M A Niessen

J Mass Spectrom. 2013 Jun;48(6):718-31.

PMID: 23722963

1

X-ray Structure of p38α Bound to TAK-715: Comparison With Three Classic Inhibitors

Rita Azevedo, Mario van Zeeland, Hans Raaijmakers, Bert Kazemier, Jacob de Vlieg, Arthur Oubrie

Acta Crystallogr D Biol Crystallogr. 2012 Aug;68(Pt 8):1041-50.

PMID: 22868770

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