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Takinib

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For Research Use Only | Not For Clinical Use
CATAP1111556376
CAS1111556-37-6
Molecular Weight322.36
Description≥98% (HPLC)
SolubilityDMSO: 2 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

A Highly Selective Inhibitor of interleukin-1 Receptor-Associated Kinases 1/4 (IRAK-1/4) Delineates the Distinct Signaling Roles of IRAK-1/4 and the TAK1 Kinase

Scott A Scarneo, Philip F Hughes, Kelly W Yang, David A Carlson, Deepak Gurbani, Kenneth D Westover, Timothy A J Haystead

J Biol Chem. 2020 Feb 7;295(6):1565-1574.

PMID: 31914413

1

Genetic and Pharmacological Validation of TAK1 Inhibition in Macrophages as a Therapeutic Strategy to Effectively Inhibit TNF Secretion

Scott A Scarneo, Antoine Mansourati, Liesl S Eibschutz, Juliane Totzke, Jose R Roques, David Loiselle, David Carlson, Philip Hughes, Timothy A J Haystead

Sci Rep. 2018 Nov 19;8(1):17058.

PMID: 30451876

1

Pharmacological Inhibition of TAK1, With the Selective Inhibitor Takinib, Alleviates Clinical Manifestation of Arthritis in CIA Mice

Scott A Scarneo, Liesl S Eibschutz, Phillip J Bendele, Kelly W Yang, Juliane Totzke, Philip Hughes, David A Fox, Timothy A J Haystead

Arthritis Res Ther. 2019 Dec 17;21(1):292.

PMID: 31847895

1

Plasmodium PK9 Inhibitors Promote Growth of Liver-Stage Parasites

Rene Raphemot, Amber Leigh Eubanks, Maria Toro-Moreno, Rechel Anne Geiger, Philip Floyd Hughes, Kuan-Yi Lu, Timothy Arthur James Haystead, Emily Rose Derbyshire

Cell Chem Biol. 2019 Mar 21;26(3):411-419.e7.

PMID: 30595530

1

Takinib, a Selective TAK1 Inhibitor, Broadens the Therapeutic Efficacy of TNF-α Inhibition for Cancer and Autoimmune Disease

Juliane Totzke, Deepak Gurbani, Rene Raphemot, Philip F Hughes, Khaldon Bodoor, David A Carlson, David R Loiselle, Asim K Bera, Liesl S Eibschutz, Marisha M Perkins, Amber L Eubanks, Phillip L Campbell, etc.

Cell Chem Biol. 2017 Aug 17;24(8):1029-1039.e7.

PMID: 28820959

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