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TCN-201

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For Research Use Only | Not For Clinical Use
CATAP852918026
CAS852918-02-6
Structure
MDL NumberMFCD06683895
Molecular Weight461.89
InChI KeyFYIBXBFDXNPBSF-UHFFFAOYSA-N
Description≥98% (HPLC)
SolubilityDMSO: 5 mg/mL (clear solution)
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

Diverse Modes of NMDA Receptor Positive Allosteric Modulation: Mechanisms and Consequences

David H Hackos, Jesse E Hanson

Neuropharmacology. 2017 Jan;112(Pt A):34-45.

PMID: 27484578

1

Sensitivity of N-methyl-D-aspartate Receptor-Mediated Excitatory Postsynaptic Potentials and Synaptic Plasticity to TCN 201 and TCN 213 in Rat Hippocampal Slices

Yukitoshi Izumi, Charles F Zorumski

J Pharmacol Exp Ther. 2015 Feb;352(2):267-73.

PMID: 25413830

1

Systematic Variation of the Benzenesulfonamide Part of the GluN2A Selective NMDA Receptor Antagonist TCN-201

Sebastian L Müller, Julian A Schreiber, Dirk Schepmann, Nathalie Strutz-Seebohm, Guiscard Seebohm, Bernhard Wünsch

Eur J Med Chem. 2017 Mar 31;129:124-134.

PMID: 28222314

1

Systematic Variation of the Benzoylhydrazine Moiety of the GluN2A Selective NMDA Receptor Antagonist TCN-201

Julian A Schreiber, Sebastian L Müller, Stefanie E Westphälinger, Dirk Schepmann, Nathalie Strutz-Seebohm, Guiscard Seebohm, Bernhard Wünsch

Eur J Med Chem. 2018 Oct 5;158:259-269.

PMID: 30218911

1

TCN 201 Selectively Blocks GluN2A-containing NMDARs in a GluN1 Co-Agonist Dependent but Non-Competitive Manner

S Edman, S McKay, L J Macdonald, M Samadi, M R Livesey, G E Hardingham, D J A Wyllie

Neuropharmacology. 2012 Sep;63(3):441-9.

PMID: 22579927

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