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TDP2 active human

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For Research Use Only | Not For Clinical Use
CATIAR42415177
Descriptionrecombinant, expressed in baculovirus infected Sf9 cells, ≥87% (SDS-PAGE)
Assay≥87% (SDS-PAGE)
Formaqueous solution
Size20UG
Storage Conditions−70°C
1

Biochemical Characterization of Human tyrosyl-DNA Phosphodiesterase 2 (TDP2/TTRAP): A Mg(2+)/Mn(2+)-dependent Phosphodiesterase Specific for the Repair of Topoisomerase Cleavage Complexes

Rui Gao, Shar-yin N Huang, Christophe Marchand, Yves Pommier

J Biol Chem. 2012 Aug 31;287(36):30842-52.

PMID: 22822062

1

Crystal Structure of Human Nocturnin Catalytic Domain

Michael A Estrella, Jin Du, Alexei Korennykh

Sci Rep. 2018 Nov 2;8(1):16294.

PMID: 30389976

1

Deazaflavin Inhibitors of Tyrosyl-DNA Phosphodiesterase 2 (TDP2) Specific for the Human Enzyme and Active Against Cellular TDP2

Christophe Marchand, Monica Abdelmalak, Jayakanth Kankanala, Shar-Yin Huang, Evgeny Kiselev, Katherine Fesen, Kayo Kurahashi, Hiroyuki Sasanuma, Shunichi Takeda, Hideki Aihara, Zhengqiang Wang, Yves Pommier

ACS Chem Biol. 2016 Jul 15;11(7):1925-33.

PMID: 27128689

1

Mitochondrial tyrosyl-DNA Phosphodiesterase 2 and Its TDP2

Shar-Yin N Huang, Ilaria Dalla Rosa, Stephanie A Michaels, David V Tulumello, Keli Agama, Salim Khiati, Sae Rin Jean, Simone A Baechler, Valentina M Factor, Sudhir Varma, Junko Murai, Lisa M Miller Jenkins, etc.

EMBO Rep. 2018 Mar;19(3):e42139.

PMID: 29438979

1

Novel Deazaflavin tyrosyl-DNA Phosphodiesterase 2 (TDP2) Inhibitors

Evgeny Kiselev, Azhar Ravji, Jayakanth Kankanala, Jiashu Xie, Zhengqiang Wang, Yves Pommier

DNA Repair (Amst). 2020 Jan;85:102747.

PMID: 31775111

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