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Thiolutin

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For Research Use Only | Not For Clinical Use
CATAP87116
CAS87-11-6
Structure
MDL NumberMFCD07370147
Molecular Weight228.29
InChI KeyUGZYFXMSMFMTSM-UHFFFAOYSA-N
Descriptionfrom Streptomyces luteosporeus, ≥95% (HPLC)
SolubilityDMSO: 0.90 - 1.10 mg/ml, clear, yellow
Assay≥95% (HPLC)
Size1MG
Storage Conditions−20°C
1

Identification and Characterization of the Biosynthetic Gene Cluster of Thiolutin, a Tumor Angiogenesis Inhibitor, in Saccharothrix Algeriensis NRRL B-24137

Sheng Huang, Ming Him Tong, Zhiwei Qin, Zixin Deng, Hai Deng, Yi Yu

Anticancer Agents Med Chem. 2015;15(3):277-84.

PMID: 25353334

1

Inhibition of Messenger Ribonucleic Acid Synthesis in Escherichia Coli by Thiolutin

G G Khachatourians, D J Tipper

J Bacteriol. 1974 Sep;119(3):795-804.

PMID: 4604615

1

Thiolutin Inhibits Endothelial Cell Adhesion by Perturbing Hsp27 Interactions With Components of the Actin and Intermediate Filament Cytoskeleton

Yifeng Jia, Shiaw-Lin Wu, Jeff S Isenberg, Shujia Dai, John M Sipes, Lyndsay Field, Bixi Zeng, Russell W Bandle, Lisa A Ridnour, David A Wink, Ramani Ramchandran, Barry L Karger, David D Roberts

Cell Stress Chaperones. 2010 Mar;15(2):165-81.

PMID: 19579057

1

Thiolutin Is a Zinc Chelator That Inhibits the Rpn11 and Other JAMM Metalloproteases

Linda Lauinger, Jing Li, Anton Shostak, Ibrahim Avi Cemel, Nati Ha, Yaru Zhang, Philipp E Merkl, Simon Obermeyer, Nicolas Stankovic-Valentin, Tobias Schafmeier, Walter J Wever, Albert A Bowers, Kyle P Carter, etc.

Nat Chem Biol. 2017 Jul;13(7):709-714.

PMID: 28459440

1

Thiolutin, an Inhibitor of HUVEC Adhesion to Vitronectin, Reduces Paxillin in HUVECs and Suppresses Tumor Cell-Induced Angiogenesis

K Minamiguchi, H Kumagai, T Masuda, M Kawada, M Ishizuka, T Takeuchi

Int J Cancer. 2001 Aug 1;93(3):307-16.

PMID: 11433393

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