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Tienilic Acid

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For Research Use Only | Not For Clinical Use
CATAP40180049
CAS40180-04-9
MDL NumberMFCD00867339
Molecular Weight331.17
EC Number254-826-3
InChI KeyAGHANLSBXUWXTB-UHFFFAOYSA-N
Description≥98% (HPLC)
SolubilityDMSO: 5 mg/mL (clear solution)
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions−20°C
1

Antigenic Targets in Tienilic Acid Hepatitis. Both Cytochrome P450 2C11 and 2C11-tienilic Acid Adducts Are Transported to the Plasma Membrane of Rat Hepatocytes and Recognized by Human Sera

M A Robin, M Maratrat, M Le Roy, F P Le Breton, E Bonierbale, P Dansette, F Ballet, D Mansuy, D Pessayre

J Clin Invest. 1996 Sep 15;98(6):1471-80.

PMID: 8823314

1

Immune Mechanisms in Tienilic Acid Associated Hepatotoxicity

J Neuberger, R Williams

Gut. 1989 Apr;30(4):515-9.

PMID: 2714684

1

Involvement of Cytochrome P450-mediated Metabolism in Tienilic Acid Hepatotoxicity in Rats

Takayoshi Nishiya, Michiyuki Kato, Takami Suzuki, Chikako Maru, Hiroko Kataoka, Chiharu Hattori, Kazuhiko Mori, Toshimasa Jindo, Yorihisa Tanaka, Sunao Manabe

Toxicol Lett. 2008 Dec 15;183(1-3):81-9.

PMID: 18992796

1

Metabolic Hydroxylation of the Thiophene Ring: Isolation of 5-hydroxy-tienilic Acid as the Major Urinary Metabolite of Tienilic Acid in Man and Rat

D Mansuy, P M Dansette, C Foures, M Jaouen, G Moinet, N Bayer

Biochem Pharmacol. 1984 May 1;33(9):1429-35.

PMID: 6732860

1

Tienilic Acid in Patients With Impaired Renal Function

A Eisalo, K J Tötterman, E Haapanen

Acta Med Scand Suppl. 1982;668:110-3.

PMID: 6762807

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