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TIQ-A

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For Research Use Only | Not For Clinical Use
CATAP420849225
CAS420849-22-5
Structure
MDL NumberMFCD06407947
Molecular Weight201.24
InChI KeyLQJVOLSLAFIXSV-UHFFFAOYSA-N
Description≥98% (HPLC), solid
SolubilityDMSO: soluble 16 mg/mL
Assay≥98% (HPLC)
Formsolid
Size1MG, 5MG
Storage Conditions2-8°C
1

Derivatives of a PARP Inhibitor TIQ-A through the Synthesis of 8-Alkoxythieno[2,3- c]isoquinolin-5(4 H)-ones

Mirko M Maksimainen, Antti Nurmesjärvi, Reima A Terho, Michael D Threadgill, Lari Lehtiö, Juha P Heiskanen

ACS Omega. 2020 May 28;5(22):13447-13453.

PMID: 32548533

1

Family-wide Chemical Profiling and Structural Analysis of PARP and Tankyrase Inhibitors

Elisabet Wahlberg, Tobias Karlberg, Ekaterina Kouznetsova, Natalia Markova, Antonio Macchiarulo, Ann-Gerd Thorsell, Ewa Pol, Åsa Frostell, Torun Ekblad, Delal Öncü, Björn Kull, Graeme Michael Robertson, etc.

Nat Biotechnol. 2012 Feb 19;30(3):283-8.

PMID: 22343925

1

Metabolism and Brain Accumulation of Tetrahydroisoquinoline (TIQ) a Possible Parkinsonism Inducing Substance, in an Animal Model of a Poor Debrisoquine Metabolizer

S Ohta, O Tachikawa, Y Makino, Y Tasaki, M Hirobe

Life Sci. 1990;46(8):599-605.

PMID: 2308469

1

Molecular Cloning of Mouse Liver Flavin Containing Monooxygenase (FMO1) cDNA and Characterization of the Expression Product: Metabolism of the Neurotoxin, 1,2,3,4-tetrahydroisoquinoline (TIQ)

K Itoh, K Nakamura, T Kimura, S Itoh, T Kamataki

J Toxicol Sci. 1997 Feb;22(1):45-56.

PMID: 9076656

1

PARP-1-regulated TNF-α Expression in the Dorsal Root Ganglia and Spinal Dorsal Horn Contributes to the Pathogenesis of Neuropathic Pain in Rats

Yan Gao, Liying Bai, Wenjuan Zhou, Yin Yang, Jian Zhang, Liren Li, Mingjun Jiang, Yang Mi, Tong-Tong Li, Xuan Zhang, Wei Zhang, Ji-Tian Xu

Brain Behav Immun. 2020 Apr 10;S0889-1591(20)30022-2.

PMID: 32283287

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