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Tonabersat

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For Research Use Only | Not For Clinical Use
CATAP175013840
CAS175013-84-0
Structure
MDL NumberMFCD00944458
Molecular Weight391.82
InChI KeyXLIIRNOPGJTBJD-ROUUACIJSA-N
Description≥98% (HPLC)
SolubilityDMSO: 20 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

A Resurging Boom in New Drugs for Epilepsy and Brain Disorders

Iyan Younus, Doodipala Samba Reddy

Expert Rev Clin Pharmacol. 2018 Jan;11(1):27-45.

PMID: 28956955

1

Carcinoma-astrocyte Gap Junctions Promote Brain Metastasis by cGAMP Transfer

Qing Chen, Adrienne Boire, Xin Jin, Manuel Valiente, Ekrem Emrah Er, Alejandro Lopez-Soto, Leni Jacob, Ruzeen Patwa, Hardik Shah, Ke Xu, Justin R Cross, Joan Massagué

Nature. 2016 May 26;533(7604):493-498.

PMID: 27225120

1

Involvement of Gap Junction Channels in the Pathophysiology of Migraine With Aura

Denis Sarrouilhe, Catherine Dejean, Marc Mesnil

Front Physiol. 2014 Feb 25;5:78.

PMID: 24611055

1

Tonabersat Prevents Inflammatory Damage in the Central Nervous System by Blocking Connexin43 Hemichannels

Yeri Kim, Jarred M Griffin, Mohd N Mat Nor, Jie Zhang, Peter S Freestone, Helen V Danesh-Meyer, Ilva D Rupenthal, Monica Acosta, Louise F B Nicholson, Simon J O'Carroll, Colin R Green

Neurotherapeutics. 2017 Oct;14(4):1148-1165.

PMID: 28560708

1

Tonabersat, a Gap-Junction Modulator: Efficacy and Safety in Two Randomized, Placebo-Controlled, Dose-Ranging Studies of Acute Migraine

S D Silberstein, J Schoenen, H Göbel, H C Diener, A H Elkind, J A Klapper, R A Howard

Cephalalgia. 2009 Nov;29 Suppl 2:17-27.

PMID: 19723122

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