CAS 123948-87-8 (free base) Topotecan hydrochloride hydrate

CAT	ALP123948878
CAS	123948-87-8 (free base)
MDL Number	MFCD00870670
Molecular Weight	421.45 (anhydrous free base basis)
InChI Key	UCFGDBYHRUNTLO-QHCPKHFHSA-N

Description	≥98% (HPLC and enzymatic)
Solubility	DMSO: ≥20 mg/mL
Assay	≥98% (HPLC and enzymatic)
Color	yellow
Form	powder; protect from light
Size	10MG, 50MG
Storage Conditions	−20°C

1

A Study of Variable Hydration States in Topotecan Hydrochloride

Frederick G Vogt, Philip C Dell'Orco, Ann M Diederich, Qiaogong Su, Jeffery L Wood, Gary E Zuber, Lee M Katrincic, Ronald L Mueller, David J Busby, Charles W Debrosse

J Pharm Biomed Anal. 2006 Mar 18;40(5):1080-8.

PMID: 16242889

1

Comparison of DC Bead-irinotecan and DC Bead-topotecan Drug Eluting Beads for Use in Locoregional Drug Delivery to Treat Pancreatic Cancer

Richard E J Forster, Sharon A Small, Yiqing Tang, Clare L Heaysman, Andrew W Lloyd, Wendy Macfarlane, Gary J Phillips, Milan D Antonijevic, Andrew L Lewis

J Mater Sci Mater Med. 2010 Sep;21(9):2683-90.

PMID: 20563626

1

Influence of the Cisplatin Hydration Schedule on Topotecan Pharmacokinetics

H Gelderblom, W J Loos, A Sparreboom, O Soepenberg, M J A de Jonge, D M van Boven-van Zomeren, J Verweij

Eur J Cancer. 2003 Jul;39(11):1542-6.

PMID: 12855260

1

Preparation, Optimization, and Characterization of Topotecan Loaded PEGylated Liposomes Using Factorial Design

Amir Masoud Vali, Taiebeh Toliyat, Bijan Shafaghi, Simin Dadashzadeh

Drug Dev Ind Pharm. 2008 Jan;34(1):10-23.

PMID: 18214751

1

The Effect of PEG Coating on in Vitro Cytotoxicity and in Vivo Disposition of Topotecan Loaded Liposomes in Rats

S Dadashzadeh, A M Vali, M Rezaie

Int J Pharm. 2008 Apr 2;353(1-2):251-9.

PMID: 18191511

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