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Trapoxin A

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For Research Use Only | Not For Clinical Use
CATAP133155892
CAS133155-89-2
Structure
Molecular Weight602.72
Description≥98% (HPLC), from Helicoma ambiens
SolubilityDMSO: soluble 0.9-1.10 mg/ml, clear, colorless to faintly yellow (may be further diluted 20 fold in H2O); chloroform: soluble; methanol: soluble
Assay≥98% (HPLC)
Formsolid
Size1MG, 5MG
Storage Conditions−20°C
1

Binding of the Microbial Cyclic Tetrapeptide Trapoxin A to the Class I Histone Deacetylase HDAC8

Nicholas J Porter, David W Christianson

ACS Chem Biol. 2017 Sep 15;12(9):2281-2286.

PMID: 28846375

1

Histone Deacetylase Inhibitor (Trapoxin A) Enhances Stemness Properties in Adipose Tissue Derived Mesenchymal Stem Cells

Leila Mousazadeh, Effat Alizadeh, Nosratollah Zarghami, Shahryar Hashemzadeh, Sedigheh Fekri Aval, Leili Hasanifard, Roya Herizchi

Drug Res (Stuttg). 2018 Aug;68(8):450-456.

PMID: 29482257

1

Kinetic Tuning of HDAC Inhibitors Affords Potent Inducers of Progranulin Expression

Carlos Moreno-Yruela, Daniel M Fass, Chialin Cheng, Joachim Herz, Christian A Olsen, Stephen J Haggarty

ACS Chem Neurosci. 2019 Aug 21;10(8):3769-3777.

PMID: 31330099

1

Structure of a New Cyclotetrapeptide Trapoxin A

H Nakai, K Nagashima, H Itazaki

Acta Crystallogr C. 1991 Jul 15;47 ( Pt 7):1496-9.

PMID: 1930826

1

Total Synthesis of Trapoxin A, a Fungal HDAC Inhibitor From Helicoma Ambiens

Phil Servatius, Uli Kazmaier

J Org Chem. 2018 Sep 21;83(18):11341-11349.

PMID: 30079728

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