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Trichostatin A

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For Research Use Only | Not For Clinical Use
CATAP58880196-A
CAS58880-19-6
Structure
MDL NumberMFCD03848392
Molecular Weight302.37
InChI KeyRTKIYFITIVXBLE-QEQCGCAPSA-N
Description≥98% (HPLC), from Streptomyces sp.
Solubilitymethanol: soluble 1.90-2.10 mg/mL, clear, colorless to faint yellow or tan; DMF: soluble; DMSO: soluble; H2O: insoluble; acetone: slightly soluble; acetonitrile: soluble; benzene: slightly soluble; chloroform: slightly soluble; ethanol: soluble; ethyl acetate: slightly soluble; lower alcohols: soluble
Assay≥98% (HPLC)
Size1MG, 5MG
Storage Conditions−20°C
1

Trichostatin A Inhibits Deacetylation of Histone H3 and p53 by SIRT6

Marci Wood, Stacia Rymarchyk, Song Zheng, Yana Cen

Arch Biochem Biophys. 2018 Jan 15;638:8-17.

PMID: 29233643

1

Trichostatin A Modulates the Macrophage Phenotype by Enhancing Autophagy to Reduce Inflammation During Polymicrobial Sepsis

Shu-Nan Cui, Zhao-Yuan Chen, Xiao-Bo Yang, Lin Chen, Yi-Yi Yang, Shang-Wen Pan, Ya-Xin Wang, Ji-Qian Xu, Ting Zhou, Hai-Rong Xiao, Lu Qin, Shi-Ying Yuan, You Shang

Int Immunopharmacol. 2019 Dec;77:105973.

PMID: 31677992

1

Trichostatin A Promotes GLI1 Degradation and P21 Expression in Multiple Myeloma Cells

Yan Geng, Jing Liu, Ying Xie, Hongmei Jiang, Kai Zuo, Tao Li, Zhiqiang Liu

Cancer Manag Res. 2018 Aug 28;10:2905-2914.

PMID: 30214285

1

Trichostatin A, a Histone Deacetylase Inhibitor, Alleviates Eosinophilic Meningitis Induced by Angiostrongylus cantonensis Infection in Mice

Yanhua Zhang, Hui Xie, Wenyan Tang, Xingda Zeng, Yu Lin, Lian Xu, Lihua Xiao, Jun Xu, Zhongdao Wu, Dongjuan Yuan

Front Microbiol. 2019 Oct 4;10:2280.

PMID: 31636619

1

Trichostatin A, a Histone Deacetylase Inhibitor, Induces Synergistic Cytotoxicity With Chemotherapy via Suppression of Raf/MEK/ERK Pathway in Urothelial Carcinoma

Wei-Chou Lin, Fu-Shun Hsu, Kuan-Lin Kuo, Shing-Hwa Liu, Chia-Tung Shun, Chung-Sheng Shi, Hong-Chiang Chang, Yu-Chieh Tsai, Ming-Chieh Lin, June-Tai Wu, Yu Kuo, Po-Ming Chow, Shih-Ming Liao, Shao-Ping Yang, etc.

J Mol Med (Berl). 2018 Dec;96(12):1307-1318.

PMID: 30288546

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