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Tryptanthrin

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For Research Use Only | Not For Clinical Use
CATAP13220570-B
CAS13220-57-0
Structure
MDL NumberMFCD00012073
Molecular Weight248.24
InChI KeyVQQVWGVXDIPORV-UHFFFAOYSA-N
Description≥98% (HPLC)
SolubilityDMSO: 2 mg/mL (warmed)
Assay≥98% (HPLC)
Colorfaintly yellow to dark yellow
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

N-Benzyl/Aryl Substituted Tryptanthrin as Dual Inhibitors of Indoleamine 2,3-Dioxygenase and Tryptophan 2,3-Dioxygenase

Dan Yang, Shengnan Zhang, Xin Fang, Leilei Guo, Nan Hu, Zhanling Guo, Xishuai Li, Shuangshuang Yang, Jin Chao He, Chunxiang Kuang, Qing Yang

J Med Chem. 2019 Oct 24;62(20):9161-9174.

PMID: 31580660

1

Study on Pharmacokinetics and Tissue Distribution of Single Dose Oral Tryptanthrin in Kunming Mice by Validated Reversed-Phase High-Performance Liquid Chromatography With Ultraviolet Detection

Xiaoyan Zhang, Jie Xia, Wenjing Zhang, Yao Luo, Wenbo Sun, Wei Zhou

Integr Med Res. 2017 Sep;6(3):269-279.

PMID: 28951841

1

The Anti-Angiogenic Effect of Tryptanthrin Is Mediated by the Inhibition of Apelin Promoter Activity and Shortened mRNA Half-Life in Human Vascular Endothelial Cells

Hsin-Ning Chang, Yuan-Chieh Yeh, Ho-Yen Chueh, Jong-Hwei S Pang

Phytomedicine. 2019 May;58:152879.

PMID: 31005035

1

Tryptanthrin Prevents Oxidative Stress-Mediated Apoptosis Through AMP-activated Protein Kinase-Dependent p38 Mitogen-Activated Protein Kinase Activation

Eun Hye Jung, Ji Yun Jung, Hae Li Ko, Jae Kwang Kim, Sang Mi Park, Dae Hwa Jung, Chung A Park, Young Woo Kim, Sae Kwang Ku, Il Je Cho, Sang Chan Kim

Arch Pharm Res. 2017 Sep;40(9):1071-1086.

PMID: 28828587

1

Tryptanthrin Protects Mice Against Dextran Sulfate Sodium-Induced Colitis Through Inhibition of TNF-α/NF-κB and IL-6/STAT3 Pathways

Zheng Wang, Xue Wu, Cui-Ling Wang, Li Wang, Chen Sun, Dong-Bo Zhang, Jian-Li Liu, Yan-Ni Liang, Dong-Xin Tang, Zhi-Shu Tang

Molecules. 2018 May 2;23(5):1062.

PMID: 29724065

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