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TUG-891

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For Research Use Only | Not For Clinical Use
CATAP1374516070
CAS1374516-07-0
Molecular Weight364.41
Description≥98% (HPLC)
SolubilityDMSO: 20 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditionsroom temp
1

Characterization of the Metabolites of TUG-891 in Rat, Dog, and Human Hepatocytes Using Ultra-High-Performance Liquid Chromatography Tandem Mass Spectrometry and Nuclear Magnetic Resonance Spectroscopy

Qinghong Shi, Yang Liu, Chunyan Liu, Jingying Wang

Rapid Commun Mass Spectrom. 2020 Jun 15;34(11):e8766.

PMID: 32108961

1

Docosahexaenoic Acid and TUG-891 Activate Free Fatty acid-4 Receptor in Bovine Neutrophils

Ivan Olmo, Stefanie Teuber, Camilo Larrazabal, Pablo Alarcon, Fernanda Raipane, Rafael A Burgos, Maria A Hidalgo

Vet Immunol Immunopathol. 2019 Mar;209:53-60.

PMID: 30885306

1

Simultaneous Determination of TUG-891 and Its Metabolites in Rat Plasma Using LC-HRMS With Application to Preclinical Pharmacokinetic Study

Jiping Yi, Bin Chen, Yongzheng Bao, Jingyu Wang

Biomed Chromatogr. 2020 Apr 28;e4870.

PMID: 32346871

1

The GPR120 Agonist TUG-891 Promotes Metabolic Health by Stimulating Mitochondrial Respiration in Brown Fat

Maaike Schilperoort, Andrea D van Dam, Geerte Hoeke, Irina G Shabalina, Anthony Okolo, Aylin C Hanyaloglu, Lea H Dib, Isabel M Mol, Natarin Caengprasath, Yi-Wah Chan, Sami Damak, Anne Reifel Miller, Tamer Coskun, etc.

EMBO Mol Med. 2018 Mar;10(3):e8047.

PMID: 29343498

1

The Pharmacology of TUG-891, a Potent and Selective Agonist of the Free Fatty Acid Receptor 4 (FFA4/GPR120), Demonstrates Both Potential Opportunity and Possible Challenges to Therapeutic Agonism

Brian D Hudson, Bharat Shimpukade, Amanda E Mackenzie, Adrian J Butcher, John D Pediani, Elisabeth Christiansen, Helen Heathcote, Andrew B Tobin, Trond Ulven, Graeme Milligan

Mol Pharmacol. 2013 Nov;84(5):710-25.

PMID: 23979972

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