CAS 175178-82-2 Tyrphostin AG 1478 - Analytical Products / Alfa Chemistry

CAT	AP175178822-C
CAS	175178-82-2
MDL Number	MFCD00270914
Molecular Weight	315.75
InChI Key	GFNNBHLJANVSQV-UHFFFAOYSA-N

Description	≥98%
Solubility	0.1 M HCl: soluble <0.4 mg/mL; DMSO:methanol (1:1): soluble 10 mg/mL, clear, colorless; ethanol: soluble 10 mg/mL; methylene chloride: soluble 10 mg/mL; 0.1 M NaOH: insoluble; 2-hydroxypropyl-β-cyclodextrin: insoluble; H2O: insoluble
Assay	≥98%
Size	1MG, 5MG
Storage Conditions	2-8°C

1

Direct Inhibition of the Cloned Kv1.5 Channel by AG-1478, a Tyrosine Kinase Inhibitor

Bok Hee Choi, Jin-Sung Choi, Duck-Joo Rhie, Shin Hee Yoon, Do Sik Min, Yang-Hyeok Jo, Myung-Suk Kim, Sang June Hahn

Am J Physiol Cell Physiol. 2002 Jun;282(6):C1461-8.

PMID: 11997261

1

Fluorescence and Analytical Ultracentrifugation Analyses of the Interaction of the Tyrosine Kinase Inhibitor, Tyrphostin AG 1478-mesylate, With Albumin

Andrew H A Clayton, Matthew A Perugini, Janet Weinstock, Julie Rothacker, Keith G Watson, Antony W Burgess, Edouard C Nice

Anal Biochem. 2005 Jul 15;342(2):292-9.

PMID: 15913535

1

Opposing Effects of Cyclosporin A and Tyrphostin AG-1478 Indicate a Role for Src Protein in the Cellular Control of Mineralization

J Stekelenburg, B Y Klein, H Ben-Bassat, N Rojansky

J Cell Biochem. 1998 Oct 1;71(1):116-26.

PMID: 9736460

1

The EGFR Tyrosine Kinase Inhibitor Tyrphostin AG-1478 Causes Hypomagnesemia and Cardiac Dysfunction

William B Weglicki, Jay H Kramer, Christopher F Spurney, Joanna J Chmielinska, I Tong Mak

Can J Physiol Pharmacol. 2012 Aug;90(8):1145-9.

PMID: 22646904

1

Tyrphostin AG 1478 Preferentially Inhibits Human Glioma Cells Expressing Truncated Rather Than Wild-Type Epidermal Growth Factor Receptors

Y Han, C G Caday, A Nanda, W K Cavenee, H J Huang

Cancer Res. 1996 Sep 1;56(17):3859-61.

PMID: 8752145

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