U0126 - CAS 109511-58-2

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For Research Use Only | Not For Clinical Use

CAT	AP109511582-B
CAS	109511-58-2
Structure
Molecular Weight	380.49

Description	U0126, CAS 109511-58-2, is a potent and specific inhibitor of MEK1 (IC₅₀ = 72 nM) and MEK2 (IC₅₀ = 58 nM). The inhibition is noncompetitive with respect to both ATP and ERK.
Solubility	DMSO: 200 mg/mL
Assay	≥98% (HPLC)
Color	white
Form	solid; protect from light
Size	1MG, 5MG, 10MG, 20MG
Storage Conditions	-20C

Aquaporin-1 Translocation and Degradation Mediates the Water Transportation Mechanism of Acetazolamide

Jianzhao Zhang, Yu An, Junwei Gao, Jing Han, Xueyang Pan, Yan Pan, Lu Tie, Xuejun Li

PLoS One. 2012;7(9):e45976.

PMID: 23029347

MAPK Signaling Pathways Regulate Mitochondrial-Mediated Apoptosis Induced by Isoorientin in Human Hepatoblastoma Cancer Cells

Li Yuan, Jing Wang, Haifang Xiao, Wanqiang Wu, Yutang Wang, Xuebo Liu

Food Chem Toxicol. 2013 Mar;53:62-8.

PMID: 23220614

Tyrosine Phosphorylation of p125(Fak), p130(Cas), and Paxillin Does Not Require Extracellular Signal-Regulated Kinase Activation in Swiss 3T3 Cells Stimulated by Bombesin or Platelet-Derived Growth Factor

D Leopoldt, H F Yee Jr, S Saab, E Rozengurt

J Cell Physiol. 2000 May;183(2):208-20.

PMID: 10737896

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