UCN-01

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For Research Use Only | Not For Clinical Use

CAT	AP112953114
CAS	112953-11-4
Structure
Molecular Weight	482.53
InChI Key	PBCZSGKMGDDXIJ-KRUBCLEUSA-N

7-hydroxy-staurosporine, UCN-01, Induces DNA Damage Response, and Autophagy in Human Osteosarcoma U2-OS Cells

Wei-Chih Lien, Ting-Yu Chen, Shi-Yuan Sheu, Tzu-Chien Lin, Fu-Chi Kang, Chung-Hsing Yu, Ta-Shen Kuan, Bu-Miin Huang, Chia-Yih Wang

J Cell Biochem. 2018 Jun;119(6):4729-4741.

PMID: 29280173

Caspase-9 Mediates Puma Activation in UCN-01-induced Apoptosis

C Nie, Y Luo, X Zhao, N Luo, A Tong, X Liu, Z Yuan, C Wang, Y Wei

Cell Death Dis. 2014 Oct 30;5(10):e1495.

PMID: 25356864

UCN-01 and UCN-02, New Selective Inhibitors of Protein Kinase C. II. Purification, Physico-Chemical Properties, Structural Determination and Biological Activities

I Takahashi, Y Saitoh, M Yoshida, H Sano, H Nakano, M Morimoto, T Tamaoki

J Antibiot (Tokyo). 1989 Apr;42(4):571-6.

PMID: 2656615

UCN-01 Induces S and G2/M Cell Cycle Arrest Through the p53/p21(waf1) or CHK2/CDC25C Pathways and Can Suppress Invasion in Human Hepatoma Cell Lines

Guoyi Wu, Nan Lin, Linan Xu, Bo Liu, Mark A Feitelson

BMC Cancer. 2013 Mar 28;13:167.

PMID: 23537372

UCN-01 Kyowa Hakko Kogyo Co

K Grosios

Curr Opin Investig Drugs. 2001 Feb;2(2):287-97.

PMID: 11816846

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CAT	Size	Form	Description	Price
AP112953114-1	1MG, 5MG	powder	≥97% (HPLC), powder	Inquiry
AP112953114-2	500μG	solid; protect from light	A cell-permeable Staurosporine derived anticancer agent that reversibly and ATP-competitively inhibits several protein kinases.	Inquiry

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