USP14 Inhibitor, IU1 - Analytical Products / Alfa Chemistry

CAT	IAR42410930
Molecular Weight	300.37

Description	The USP14 Inhibitor, IU1 controls the biological activity of USP14. This small molecule/inhibitor is primarily used for Cell Structure applications.
Solubility	DMSO: 50 mg/mL
Assay	≥90% (HPLC)
Color	beige
Form	solid; protect from light
Size	10MG
Storage Conditions	+2C to +8C

1

An Inhibitor of the Proteasomal Deubiquitinating Enzyme USP14 Induces Tau Elimination in Cultured Neurons

Monica Boselli, Byung-Hoon Lee, Jessica Robert, Miguel A Prado, Sang-Won Min, Chialin Cheng, M Catarina Silva, Changhyun Seong, Suzanne Elsasser, Ketki M Hatle, Timothy C Gahman, Steven P Gygi, Stephen J Haggarty, etc.

J Biol Chem. 2017 Nov 24;292(47):19209-19225.

PMID: 28972160

1

Inhibition of USP14 Enhances the Sensitivity of Breast Cancer to Enzalutamide

Xiaohong Xia, Chuyi Huang, Yuning Liao, Yuan Liu, Jinchan He, Zhiqiang Guo, Lili Jiang, Xuejun Wang, Jinbao Liu, Hongbiao Huang

J Exp Clin Cancer Res. 2019 May 24;38(1):220.

PMID: 31126320

1

Neurotoxic Mechanisms by Which the USP14 Inhibitor IU1 Depletes Ubiquitinated Proteins and Tau in Rat Cerebral Cortical Neurons: Relevance to Alzheimer's Disease

Magdalena J Kiprowska, Anna Stepanova, Dustin R Todaro, Alexander Galkin, Arthur Haas, Scott M Wilson, Maria E Figueiredo-Pereira

Biochim Biophys Acta Mol Basis Dis. 2017 Jun;1863(6):1157-1170.

PMID: 28372990

1

Small Molecule Inhibitors Reveal Allosteric Regulation of USP14 via Steric Blockade

Yiwei Wang, Yuxuan Jiang, Shan Ding, Jiawang Li, Ningjing Song, Yujing Ren, Danning Hong, Cai Wu, Bin Li, Feng Wang, Wei He, Jiawei Wang, Ziqing Mei

Cell Res. 2018 Dec;28(12):1186-1194.

PMID: 30254335

1

USP14 Inhibitor IU1 Prevents Ventilator-Induced Lung Injury in Rats

Y-H Xu, N-L Guo

Cell Mol Biol (Noisy-le-grand). 2014 Sep 7;60(2):50-4.

PMID: 25198582

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