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VAS2870

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For Research Use Only | Not For Clinical Use
CATAP722456317
CAS722456-31-7
MDL NumberMFCD03407188
Molecular Weight360.39
InChI KeyHZSOKHVVANONPV-UHFFFAOYSA-N
Description≥97% (HPLC)
SolubilityDMSO: ≥5 mg/mL
Assay≥97% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditionsroom temp
1

Evolution of NADPH Oxidase Inhibitors: Selectivity and Mechanisms for Target Engagement

Sebastian Altenhöfer, Kim A Radermacher, Pamela W M Kleikers, Kirstin Wingler, Harald H H W Schmidt

Antioxid Redox Signal. 2015 Aug 10;23(5):406-27.

PMID: 24383718

1

NOX4-dependent Fatty Acid Oxidation Promotes NLRP3 Inflammasome Activation in Macrophages

Jong-Seok Moon, Kiichi Nakahira, Kuei-Pin Chung, Gina M DeNicola, Michael Jakun Koo, Maria A Pabón, Kristen T Rooney, Joo-Heon Yoon, Stefan W Ryter, Heather Stout-Delgado, Augustine M K Choi

Nat Med. 2016 Sep;22(9):1002-12.

PMID: 27455510

1

Off-target Thiol Alkylation by the NADPH Oxidase Inhibitor 3-benzyl-7-(2-benzoxazolyl)thio-1,2,3-triazolo[4,5-d]pyrimidine (VAS2870)

Qi-An Sun, Douglas T Hess, Benlian Wang, Masaru Miyagi, Jonathan S Stamler

Free Radic Biol Med. 2012 May 1;52(9):1897-902.

PMID: 22406319

1

Pharmacological Characterization of the Seven Human NOX Isoforms and Their Inhibitors

Fiona Augsburger, Aleksandra Filippova, Delphine Rasti, Tamara Seredenina, Magdalena Lam, Ghassan Maghzal, Zahia Mahiout, Pidder Jansen-Dürr, Ulla G Knaus, James Doroshow, Roland Stocker, Karl-Heinz Krause, etc.

Redox Biol. 2019 Sep;26:101272.

PMID: 31330481

1

VAS2870 Inhibits Histamine-Induced Calcium Signaling and vWF Secretion in Human Umbilical Vein Endothelial Cells

Pavel V Avdonin, Elena Yu Rybakova, Piotr P Avdonin, Sergei K Trufanov, Galina Yu Mironova, Alexandra A Tsitrina, Nikolay V Goncharov

Cells. 2019 Feb 23;8(2):196.

PMID: 30813397

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