0

VE-821

INQUIRY Add to cart
For Research Use Only | Not For Clinical Use
CATAP1232410499
CAS1232410-49-9
Structure
MDL NumberMFCD19443686
Molecular Weight368.41
InChI KeyDUIHHZKTCSNTGM-UHFFFAOYSA-N
Description≥98% (HPLC)
SolubilityDMSO: 10 mg/mL, clear; H2O: 10 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions−20°C
1

ATR Inhibitors VE-821 and VX-970 Sensitize Cancer Cells to Topoisomerase I Inhibitors by Disabling DNA Replication Initiation and Fork Elongation Responses

Rozenn Jossé, Scott E Martin, Rajarshi Guha, Pinar Ormanoglu, Thomas D Pfister, Philip M Reaper, Christopher S Barnes, Julie Jones, Peter Charlton, John R Pollard, Joel Morris, James H Doroshow, Yves Pommier

Cancer Res. 2014 Dec 1;74(23):6968-79.

PMID: 25269479

1

Radio-sensitizing Effects of VE-821 and Beyond: Distinct Phosphoproteomic and Metabolomic Changes After ATR Inhibition in Irradiated MOLT-4 Cells

Barbora Šalovská, Hana Janečková, Ivo Fabrik, Radana Karlíková, Lucie Čecháková, Martin Ondrej, Marek Link, David Friedecký, Aleš Tichý

PLoS One. 2018 Jul 12;13(7):e0199349.

PMID: 30001349

1

Sulfoximines as ATR Inhibitors: Analogs of VE-821

Christine M M Hendriks, Jörg Hartkamp, Stefan Wiezorek, Anne-Dorothee Steinkamp, Giulia Rossetti, Bernhard Lüscher, Carsten Bolm

Bioorg Med Chem Lett. 2017 Jun 15;27(12):2659-2662.

PMID: 28479198

1

The Novel ATR Inhibitor VE-821 Increases Sensitivity of Pancreatic Cancer Cells to Radiation and Chemotherapy

Remko Prevo, Emmanouil Fokas, Philip M Reaper, Peter A Charlton, John R Pollard, W Gillies McKenna, Ruth J Muschel, Thomas B Brunner

Cancer Biol Ther. 2012 Sep;13(11):1072-81.

PMID: 22825331

1

VE-821, an ATR Inhibitor, Causes Radiosensitization in Human Tumor Cells Irradiated With High LET Radiation

Hiroshi Fujisawa, Nakako Izumi Nakajima, Shigeaki Sunada, Younghyun Lee, Hirokazu Hirakawa, Hirohiko Yajima, Akira Fujimori, Mitsuru Uesaka, Ryuichi Okayasu

Radiat Oncol. 2015 Aug 19;10:175.

PMID: 26286029

  • Verification code
Contact Us

Send Us a Request

What is your specific need? We will do everything we can to meet your expectations.
Online Inquiry

Inquiry

For any inquiry, question or recommendation, please call: or fill out the following form.

  • Verification code

Head Office

  • Tel:
  • Email:

Follow us on

qrcode