CAS 38214-71-0 VRT-532 - Analytical Products / Alfa Chemistry

CAT	AP38214710
CAS	38214-71-0
Structure
Molecular Weight	250.30

Description	≥98% (HPLC)
Solubility	DMSO: >20 mg/mL
Assay	≥98% (HPLC)
Form	solid
Size	5MG, 25MG
Storage Conditions	−20°C

1

A Small-Molecule Modulator Interacts Directly With deltaPhe508-CFTR to Modify Its ATPase Activity and Conformational Stability

Leigh Wellhauser, Patrick Kim Chiaw, Stan Pasyk, Canhui Li, Mohabir Ramjeesingh, Christine E Bear

Mol Pharmacol. 2009 Jun;75(6):1430-8.

PMID: 19339490

1

CFTR Modulators for the Treatment of Cystic Fibrosis

Rebecca S Pettit, Chris Fellner

P T. 2014 Jul;39(7):500-11.

PMID: 25083129

1

Comparison of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) and Ciliary Beat Frequency Activation by the CFTR Modulators Genistein, VRT-532, and UCCF-152 in Primary Sinonasal Epithelial Cultures

Bryant T Conger, Shaoyan Zhang, Daniel Skinner, Stephen B Hicks, Eric J Sorscher, Steven M Rowe, Bradford A Woodworth

JAMA Otolaryngol Head Neck Surg. 2013 Aug 1;139(8):822-7.

PMID: 23949358

1

Direct Interaction of a Small-Molecule Modulator With G551D-CFTR, a Cystic Fibrosis-Causing Mutation Associated With Severe Disease

Stan Pasyk, Canhui Li, Mohabir Ramjeesingh, Christine E Bear

Biochem J. 2009 Feb 15;418(1):185-90.

PMID: 18945216

1

Regulatory Domain Phosphorylation to Distinguish the Mechanistic Basis Underlying Acute CFTR Modulators

Louise C Pyle, Annette Ehrhardt, Lisa High Mitchell, Lijuan Fan, Aixia Ren, Anjaparavanda P Naren, Yao Li, J P Clancy, Graeme B Bolger, Eric J Sorscher, Steven M Rowe

Am J Physiol Lung Cell Mol Physiol. 2011 Oct;301(4):L587-97.

PMID: 21724857

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