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WYE-125132

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For Research Use Only | Not For Clinical Use
CATAP1144068461
CAS1144068-46-1
Molecular Weight519.60
Description≥97% (HPLC)
SolubilityDMSO: 20 mg/mL, clear
Assay≥97% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions−20°C
1

Beyond Rapalog Therapy: Preclinical Pharmacology and Antitumor Activity of WYE-125132, an ATP-competitive and Specific Inhibitor of mTORC1 and mTORC2

Ker Yu, Celine Shi, Lourdes Toral-Barza, Judy Lucas, Boris Shor, Jae Eun Kim, Wei-Guo Zhang, Robert Mahoney, Christine Gaydos, Luanna Tardio, Sung Kyoo Kim, Roger Conant, Kevin Curran, Joshua Kaplan, Jeroen Verheijen, etc.

Cancer Res. 2010 Jan 15;70(2):621-31.

PMID: 20068177

1

Biochemical and Pharmacological Inhibition of mTOR by Rapamycin and an ATP-competitive mTOR Inhibitor

Ker Yu, Lourdes Toral-Barza

Methods Mol Biol. 2012;821:15-28.

PMID: 22125057

1

Requirement of the mTOR Kinase for the Regulation of Maf1 Phosphorylation and Control of RNA Polymerase III-dependent Transcription in Cancer Cells

Boris Shor, Jiang Wu, Quazi Shakey, Lourdes Toral-Barza, Celine Shi, Max Follettie, Ker Yu

J Biol Chem. 2010 May 14;285(20):15380-92.

PMID: 20233713

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