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WZ4002

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For Research Use Only | Not For Clinical Use
CATAP1213269238
CAS1213269-23-8
Structure
MDL NumberMFCD16621244
Molecular Weight494.97
InChI KeyITTRLTNMFYIYPA-UHFFFAOYSA-N
Description≥98% (HPLC)
SolubilityDMSO: 5 mg/mL, clear (warmed)
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions−20°C
1

Acquired Resistance to the Mutant-Selective EGFR Inhibitor AZD9291 Is Associated With Increased Dependence on RAS Signaling in Preclinical Models

Catherine A Eberlein, Daniel Stetson, Aleksandra A Markovets, Katherine J Al-Kadhimi, Zhongwu Lai, Paul R Fisher, Catherine B Meador, Paula Spitzler, Eiki Ichihara, Sarah J Ross, Miika J Ahdesmaki, Ambar Ahmed, etc.

Cancer Res. 2015 Jun 15;75(12):2489-500.

PMID: 25870145

1

Activation of the IGF1R Pathway Potentially Mediates Acquired Resistance to Mutant-Selective 3rd-generation EGF Receptor Tyrosine Kinase Inhibitors in Advanced Non-Small Cell Lung Cancer

Ji Hyun Park, Yun Jung Choi, Seon Ye Kim, Jung-Eun Lee, Ki Jung Sung, Sojung Park, Woo Sung Kim, Joon Seon Song, Chang-Min Choi, Young Hoon Sung, Jin Kyung Rho, Jae Cheol Lee

Oncotarget. 2016 Apr 19;7(16):22005-15.

PMID: 26980747

1

Crystal Structure of EGFR T790M/C797S/V948R in Complex With EAI045

Peng Zhao, Ming-Yu Yao, Su-Jie Zhu, Ji-Yun Chen, Cai-Hong Yun

Biochem Biophys Res Commun. 2018 Jul 20;502(3):332-337.

PMID: 29802850

1

EGFR Mutations and Resistance to Irreversible Pyrimidine-Based EGFR Inhibitors

Dalia Ercan, Hwan Geun Choi, Cai-Hong Yun, Marzia Capelletti, Ting Xie, Michael J Eck, Nathanael S Gray, Pasi A Jänne

Clin Cancer Res. 2015 Sep 1;21(17):3913-23.

PMID: 25948633

1

Targeting EGFR

Xiaoyun Lu, Lei Yu, Zhang Zhang, Xiaomei Ren, Jeff B Smaill, Ke Ding

Med Res Rev. 2018 Sep;38(5):1550-1581.

PMID: 29377179

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