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XK469

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For Research Use Only | Not For Clinical Use
CATIAR4245621
MDL NumberMFCD05861262
Molecular Weight366.73
InChI KeyNUQZXROIVGBRGR-UHFFFAOYSA-N
Description≥98% (HPLC), solid
Assay≥98% (HPLC)
Formsolid
Size5MG
Storage Conditions2-8°C
1

[Effect of XK469 and Adriamycin on the Growth of H460 Cells in Vitro and Its Mechanism]

Zhao-hui Ling, Hua Du, Chang-qing Yuan, Shu-dong Ma, Li Zheng, Zhen-hua Ding

Di Yi Jun Yi Da Xue Xue Bao. 2004 Jul;24(7):775-8.

PMID: 15257900

1

Metabolic Profile of XK469 (2(R)-[4-(7-chloro-2-quinoxalinyl)oxyphenoxy]-propionic Acid; NSC698215) in Patients and in Vitro: Low Potential for Active or Toxic Metabolites or for Drug-Drug Interactions

Lawrence W Anderson, Jerry M Collins, Raymond W Klecker, Aspandiar G Katki, Ralph E Parchment, Ramesh R Boinpally, Patricia M LoRusso, S Percy Ivy

Cancer Chemother Pharmacol. 2005 Oct;56(4):351-7.

PMID: 15895233

1

Preclinical Evaluation of 2-[4-(7-chloro-2-quinoxalinyloxy)phenoxy]-propionic Acid as a Modulator of Etoposide in Human Waldenstrom's Macroglobulinemia Xenograft Model

Edith J Mensah-Osman, Ayad M Al-Katib, Ramzi M Mohammad

Clin Cancer Res. 2003 Nov 15;9(15):5794-7.

PMID: 14654565

1

The Chemotherapeutic Agents XK469 (2-{4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy}propionic Acid) and SH80 (2-{4-[(7-bromo-2-quinolinyl)oxy]phenoxy}propionic Acid) Inhibit Cytokinesis and Promote Polyploidy and Induce Senescence

John J Reiners Jr, Miriam Kleinman, Aby Joiakim, Patricia A Mathieu

J Pharmacol Exp Ther. 2009 Mar;328(3):796-806.

PMID: 19066341

1

XK469, a Topo IIbeta Inhibitor, Induces Apoptosis in Waldenstrom's Macroglobulinemia Through Multiple Pathways

Edith Mensah-Osman, Ayad Al-Katib, Mahmoud Dandashi, Ramzi Mohammad

Int J Oncol. 2003 Dec;23(6):1637-44.

PMID: 14612935

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