CAS 146986-50-7 Y-27632 - CAS 146986-50-7 - Analytical Products / Alfa Chemistry

CAT	AP146986507
CAS	146986-50-7
Structure
Molecular Weight	247.34

Description	Y-27632A, CAS 146986-50-7, is a cell-permeable, reversible, inhibitor of Rho kinases (Ki = 140 nM for p160ROCK). Enhances survival & cloning efficiency of ESC without affecting their pluripotency.
Solubility	water: 100 mg/mL
Assay	≥95% (HPLC)
Color	white
Form	solid; desiccated; protect from light
Size	1MG, 5MG, 10MG, 100MG
Storage Conditions	-20C

1

G(i)-mediated Cas Tyrosine Phosphorylation in Vascular Endothelial Cells Stimulated With Sphingosine 1-phosphate: Possible Involvement in Cell Motility Enhancement in Cooperation With Rho-mediated Pathways

T Ohmori, Y Yatomi, H Okamoto, Y Miura, G Rile, K Satoh, Y Ozaki

J Biol Chem. 2001 Feb 16;276(7):5274-80.

PMID: 11056155

1

Ocular Hypotensive Efficacy of Src-family Tyrosine Kinase Inhibitors via Different Cellular Actions From Rock Inhibitors

Tomoko Kirihara, Atsushi Shimazaki, Masatsugu Nakamura, Nobuaki Miyawaki

Exp Eye Res. 2014 Feb;119:97-105.

PMID: 24321889

1

RhoA Is Activated During Respiratory Syncytial Virus Infection

T L Gower, M E Peeples, P L Collins, B S Graham

Virology. 2001 May 10;283(2):188-96.

PMID: 11336544

1

ROCK and mDia1 Antagonize in Rho-dependent Rac Activation in Swiss 3T3 Fibroblasts

Takahiro Tsuji, Toshimasa Ishizaki, Muneo Okamoto, Chiharu Higashida, Kazuhiro Kimura, Tomoyuki Furuyashiki, Yoshiki Arakawa, Raymond B Birge, Tetsuya Nakamoto, Hisamaru Hirai, Shuh Narumiya

J Cell Biol. 2002 May 27;157(5):819-30.

PMID: 12021256

1

Y-27632, an Inhibitor of Rho-associated Kinases, Prevents Tyrosine Phosphorylation of Focal Adhesion Kinase and Paxillin Induced by Bombesin: Dissociation From Tyrosine Phosphorylation of p130(CAS)

J Sinnett-Smith, J A Lunn, D Leopoldt, E Rozengurt

Exp Cell Res. 2001 Jun 10;266(2):292-302.

PMID: 11399057

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