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YM-58483

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For Research Use Only | Not For Clinical Use
CATAP223499307-B
CAS223499-30-7
Structure
MDL NumberMFCD00220976
Molecular Weight421.32
InChI KeyXPRZIORDEVHURQ-UHFFFAOYSA-N
Description≥98% (HPLC)
SolubilityDMSO: 10 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

Efficacy of Constant Long-Term Delivery of YM-58483 for the Treatment of Rheumatoid Arthritis

Maya Miyoshi, Shuang Liu, Asuka Morizane, Erika Takemasa, Yashuyuki Suzuki, Takeshi Kiyoi, Kazutaka Maeyama, Masaki Mogi

Eur J Pharmacol. 2018 Apr 5;824:89-98.

PMID: 29428471

1

Potent Analgesic Effects of a Store-Operated Calcium Channel Inhibitor

Ruby Gao, Xinghua Gao, Jingsheng Xia, Yuzhen Tian, James E Barrett, Yue Dai, Huijuan Hu

Pain. 2013 Oct;154(10):2034-2044.

PMID: 23778292

1

The Central Analgesic Mechanism of YM-58483 in Attenuating Neuropathic Pain in Rats

Zeyou Qi, Yaping Wang, Haocheng Zhou, Na Liang, Lin Yang, Lei Liu, Wei Zhang

Cell Mol Neurobiol. 2016 Oct;36(7):1035-43.

PMID: 26514127

1

The Suppressive Effects of YM-58483/BTP-2, a Store-Operated Ca2+ Entry Blocker, on Inflammatory Mediator Release in Vitro and Airway Responses in Vivo

Keiko Ohga, Ryuichi Takezawa, Taiji Yoshino, Toshimitsu Yamada, Yasuaki Shimizu, Jun Ishikawa

Pulm Pharmacol Ther. 2008;21(2):360-9.

PMID: 17977764

1

YM-58483, a Selective CRAC Channel Inhibitor, Prevents Antigen-Induced Airway Eosinophilia and Late Phase Asthmatic Responses via Th2 Cytokine Inhibition in Animal Models

Taiji Yoshino, Jun Ishikawa, Keiko Ohga, Tatsuaki Morokata, Ryuichi Takezawa, Hiroki Morio, Youhei Okada, Kazuo Honda, Toshimitsu Yamada

Eur J Pharmacol. 2007 Apr 10;560(2-3):225-33.

PMID: 17307161

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