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(Z)-Endoxifen

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For Research Use Only | Not For Clinical Use
CATAP112093284
CAS112093-28-4
Structure
MDL NumberMFCD09840374
Molecular Weight373.49
Description≥98% (HPLC)
SolubilityDMSO: 2 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

A Multi-Gram-Scale Stereoselective Synthesis of Z-endoxifen

Lech-Gustav Milroy, Bartjan Koning, Daphne S V Scheppingen, Nynke G L Jager, Jos H Beijnen, Jan Koek, Luc Brunsveld

Bioorg Med Chem Lett. 2018 May 1;28(8):1352-1356.

PMID: 29548575

1

Clinical Pharmacokinetics and Pharmacogenetics of Tamoxifen and Endoxifen

A B Sanchez-Spitman, J J Swen, V O Dezentje, D J A R Moes, H Gelderblom, H J Guchelaar

Expert Rev Clin Pharmacol. 2019 Jun;12(6):523-536.

PMID: 31008668

1

First-in-Human Phase I Study of the Tamoxifen Metabolite Z-Endoxifen in Women With Endocrine-Refractory Metastatic Breast Cancer

Matthew P Goetz, Vera J Suman, Joel M Reid, Don W Northfelt, Michael A Mahr, Andrew T Ralya, Mary Kuffel, Sarah A Buhrow, Stephanie L Safgren, Renee M McGovern, John Black, Travis Dockter, Tufia Haddad, etc.

J Clin Oncol. 2017 Oct 20;35(30):3391-3400.

PMID: 28854070

1

Investigational Chemotherapy and Novel Pharmacokinetic Mechanisms for the Treatment of Breast Cancer Brain Metastases

Neal Shah, Afroz S Mohammad, Pushkar Saralkar, Samuel A Sprowls, Schuyler D Vickers, Devin John, Rachel M Tallman, Brandon P Lucke-Wold, Katherine E Jarrell, Mark Pinti, Richard L Nolan, Paul R Lockman

Pharmacol Res. 2018 Jun;132:47-68.

PMID: 29604436

1

Limited Predictive Value of Achieving Beneficial Plasma (Z)-endoxifen Threshold Level by CYP2D6 Genotyping in Tamoxifen-Treated Polish Women With Breast Cancer

Ewa E Hennig, Magdalena Piatkowska, Jakub Karczmarski, Krzysztof Goryca, Elzbieta Brewczynska, Radoslaw Jazwiec, Anna Kluska, Robert Omiotek, Agnieszka Paziewska, Michal Dadlez, Jerzy Ostrowski

BMC Cancer. 2015 Aug 1;15:570.

PMID: 26232141

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