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Zibotentan

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For Research Use Only | Not For Clinical Use
CATAP186497074
CAS186497-07-4
MDL NumberMFCD09955343
Molecular Weight424.43
InChI KeyFJHHZXWJVIEFGJ-UHFFFAOYSA-N
Description≥98% (HPLC)
SolubilityDMSO: 5 mg/mL, clear (warmed)
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions−20°C
1

Castration Determines the Efficacy of ETAR Blockade in a Mouse Model of Prostate Cancer Bone Metastasis

Henry H Moon, Katrina L Clines, Mark A Cooks, Charlotte A Cialek, Marian A Esvelt, Gregory A Clines

Endocrinology. 2019 Aug 1;160(8):1786-1796.

PMID: 31173072

1

Combination Therapy of Zibotentan With Cisplatinum and Paclitaxel Is an Effective Regimen for Epithelial Ovarian Cancer

Laura Rosanò, Roberta Cianfrocca, Francesca Spinella, Valeriana Di Castro, Pier Giorgio Natali, Anna Bagnato

Can J Physiol Pharmacol. 2010 Jun;88(6):676-81.

PMID: 20628434

1

Disposition and Metabolism of the Specific Endothelin A Receptor Antagonist Zibotentan (ZD4054) in Healthy Volunteers

Jacqueline A Clarkson-Jones, Alison S J Kenyon, John Kemp, Eva M Lenz, Stuart D Oliver, Helen Swaisland

Xenobiotica. 2012 Apr;42(4):363-71.

PMID: 22014279

1

Phase 3, Randomized, Placebo-Controlled Study of Zibotentan (ZD4054) in Patients With Castration-Resistant Prostate Cancer Metastatic to Bone

Joel B Nelson, Karim Fizazi, Kurt Miller, Celestia Higano, Judd W Moul, Hideyuki Akaza, Thomas Morris, Stuart McIntosh, Kristine Pemberton, Martin Gleave

Cancer. 2012 Nov 15;118(22):5709-18.

PMID: 22786751

1

The Efficacy and Safety of Zibotentan in the Treatment of Castration-Resistant Prostate Cancer: A Meta-Analysis

Y Wu, N Shao, Z-X Shen, Q Li, Y Wang, C Li, G Ma, J Dong, X-J Lu, N-H Feng

Eur Rev Med Pharmacol Sci. 2014;18(21):3291-6.

PMID: 25487941

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