CAS 14320-04-8 Zinc phthalocyanine - Analytical Products / Alfa Chemistry

CAT	AP14320048
CAS	14320-04-8
Structure
MDL Number	MFCD00041955
Molecular Weight	577.91
EC Number	238-262-5
InChI Key	PODBBOVVOGJETB-UHFFFAOYSA-N; LUMO 3.78 eV (CV)
REAXYS Number	4121852

Description	Dye content 97 %
Size	5G, 25G

A Tumor-Targeted Ganetespib-zinc Phthalocyanine Conjugate for Synergistic Chemo-Photodynamic Therapy

Liangfeng Huang, Gaofei Wei, Xiaoqi Sun, Yali Jiang, Zeqian Huang, Yanjuan Huang, Yifeng Shen, Xiaoyu Xu, Yunhui Liao, Chunshun Zhao

Eur J Med Chem. 2018 May 10;151:294-303.

PMID: 29627724

Photodynamic Antimicrobial Chemotherapy Using Zinc Phthalocyanine Derivatives in Treatment of Bacterial Skin Infection

Zhuo Chen, Yaxin Zhang, Dong Wang, Linsen Li, Shanyong Zhou, Joy H Huang, Jincan Chen, Ping Hu, Mingdong Huang

J Biomed Opt. 2016 Jan;21(1):18001.

PMID: 26747478

Photodynamic Therapy Activity of Zinc Phthalocyanine Linked to Folic Acid and Magnetic Nanoparticles

Gauta Gold Matlou, David O Oluwole, Earl Prinsloo, Tebello Nyokong

J Photochem Photobiol B. 2018 Sep;186:216-224.

PMID: 30077918

Zinc Phthalocyanine Encapsulated in Polymer Micelles as a Potent Photosensitizer for the Photodynamic Therapy of Osteosarcoma

Wei Yu, Mingzhou Ye, Jian Zhu, Yitian Wang, Chengzhen Liang, Jianbin Tang, Huimin Tao, Youqing Shen

Nanomedicine. 2018 Jun;14(4):1099-1110.

PMID: 29462663

Zinc Phthalocyanine Labelled Polyethylene Glycol: Preparation, Characterization, Interaction With Bovine Serum Albumin and Near Infrared Fluorescence Imaging in Vivo

Feng Lv, Bo Cao, Yanli Cui, Tianjun Liu

Molecules. 2012 May 25;17(6):6348-61.

PMID: 22634844

* Products or Services Interested: Zinc phthalocyanine (14320-04-8)
* Your question
* Name
* Email
Verification Code

Case Study

Preparation of Magnetite Nanoparticles Functionalized with Zinc(II) Phthalocyanine and Aminated Chitosan

Piosik, Emilia, et al. The Journal of Physical Chemistry C 126.42 (2022): 18100-18114.

A novel synthesis of amine-functionalized chitosan-coated magnetite nanoparticles (MNPs) with zinc(II) phthalocyanine (ZnPc) fixed on their surface is presented. The synthesized ZnPc-MNP combines the superparamagnetic properties of MNPs with the photosensitivity of ZnPc, making it a promising nanomaterial for application in dual anticancer therapy based on hyperthermia and photodynamic effects.
Chitosan (0.2 g) dissolved in an acetic acid solution (1 wt%, 20 mL) was added to a solution of zinc(II) phthalocyanine (0.05 g) in DMF (10 mL). The mixture was mechanically stirred at room temperature for 40 minutes. Then, ferrous sulfate hexahydrate (1.02 g) and ferric chloride tetrahydrate (2.03 g) were added. The magnetic nanoparticles were precipitated by adding a sodium hydroxide solution (30 wt%, 10 mL). Next, epichlorohydrin (0.46 g, 5 mmol) was added, and the mixture was stirred with a magnetic stirrer at 50 °C for 2 hours. After cooling, 5 mL of sodium periodate solution (0.32 g) was added, and stirring continued at room temperature for 30 minutes. The black precipitate of nanoparticles was separated from the solution using a magnet and washed three times with deionized water. Then, a carbonate buffer solution (10 mL) and glutaraldehyde (7 wt%, 20 mL) were added, and the mixture was stirred for 1 hour. Next, ethylenediamine (EDA, 2.04 g, 20 mL) was added, and the mixture was stirred for 2 hours. Subsequently, the nanoparticles were separated from the solution using a magnet, washed three times with deionized water, and vacuum-dried at 50 °C for 24 hours.

Preparation of PCT Nanodispersions Using Zinc Phthalocyanine

Yang, Anpu, et al. Asian Journal of Pharmaceutical Sciences 17.1 (2022): 120-128.

A one-pot method was used to prepare nanodispersions (PCT) consisting of single-walled carbon nanohorns (SWCNH) and zinc phthalocyanine (ZnPc). After a single application of the PCT nanodispersion and laser treatment around the tumor, simultaneous photodynamic and photothermal therapies can completely eliminate the tumor.
Preparation of PCT Nanodispersions: Dissolve 10 mg of ZnPc in 25 mL of a DMSO/ethanol (1:1, v/v) mixed solution. The mixture is sonicated for 1 hour using an 80W probe-type ultrasonic device, with intervals of 5 seconds of operation followed by 5 seconds of rest. Then, stir for 24 hours and centrifuge at 5000 rpm for 5 minutes to obtain the supernatant, which is the saturated solution of ZnPc. Next, add 10 mg of SWCNH to the supernatant and sonicate for 1 hour, then stir for 48 hours to ensure good adsorption of ZnPc onto the SWCNH. The prepared ZnPc/SWCNH is filtered, washed several times, and dried. Finally, 2 mg of ZnPc/SWCNH is added to 2 mL of DMEM containing 10 mg of TPGS and sonicated for 1 hour to prepare the PCT nanodispersion. All operations are performed under light-protected conditions.