Common E-Cigarette Flavoring Chemicals Impair Neutrophil Phagocytosis and Oxidative Burst

Elise Hickman, Carolina A Herrera, Ilona Jaspers

Chem Res Toxicol. 2019 Jun 17;32(6):982-985.

PMID: 31117350

Abstract:

E-cigarette flavorings have not been thoroughly evaluated for inhalational toxicity. We have shown that the flavoring chemical cinnamaldehyde impairs human neutrophils, macrophages, and natural killer cells. Here we investigated the effects of other common e-liquid flavoring chemicals on phagocytosis and oxidative burst in neutrophils. We demonstrate that cinnamaldehyde and ethyl vanillin dose-dependently decrease oxidative burst and that benzaldehyde and benzaldehyde propylene glycol acetal dose-dependently impair phagocytosis. Isoamyl acetate did not affect either measure of neutrophil function. These data suggest that inhaling aromatic aldehydic flavoring chemicals, such as cinnamaldehyde, benzaldehyde, benzaldehyde propylene glycol acetal, or ethyl vanillin, could impair neutrophil function.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP121324-A	Ethyl vanillin		121-32-4	Price
AP2568254	Benzaldehyde propylene glycol acetal		2568-25-4	Price