Development of Halobetasol-loaded Nanostructured Lipid Carrier for Dermal Administration: Optimization, Physicochemical and Biopharmaceutical Behavior, and Therapeutic Efficacy

Paulina Carvajal-Vidal, María-José Fábrega, Marta Espina, Ana Cristina Calpena, M Luisa García

Nanomedicine. 2019 Aug;20:102026.

PMID: 31170512

Abstract:

Halobetasol propionate (HB) is considered a super potent drug in the group of topical corticosteroids. HB has anti-inflammatory activity, vasoconstriction properties, and due to its high skin penetration, it can cause systemic side effects. To improve its characteristics, enhance topical effectiveness and reduce penetration to systemic circulation, a study to optimize and characterize a HB-loaded lipid nanocarrier (HB-NLC) has been made by high-pressure homogenization method. The formulation is composed by HB, surfactant, glyceryl distearate and capric glycerides. The optimized HB-NLC containing 0.01% of HB and 3% of total lipid shows an average size below 200 nm with a polydispersity index ≪0.2 and an encapsulation efficiency ≫90%. The in vitro and in vivo tests indicate that the HB-NLC is not toxic, is well tolerated and has an anti-inflammatory effect because they decrease the production of Interleukins in keratinocytes and monocytes. HB-NLC is considered an alternative treatment for skin inflammatory disorders.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1323837	Glyceryl distearate		1323-83-7	Price