Discovering Less Toxic Ionic Liquids by Using the Microtox® Toxicity Test

F J Hernández-Fernández, J Bayo, A Pérez de los Ríos, M A Vicente, F J Bernal, J Quesada-Medina

Ecotoxicol Environ Saf. 2015 Jun;116:29-33.

PMID: 25748519

Abstract:

New Microtox® toxicity data of 16 ionic liquids of different cationic and anionic composition were determined. The ionic liquids 1-butyl-1-methylpyrrolidinium trifluoromethanesulfonate, [BMPyr(+)][TFO(-)], 1-butyl-1-methylpyrrolidinium chloride, [BMPyr(+)][Cl(-)], hydroxypropylmethylimidazolium fluoroacetate, [HOPMIM(+)][FCH2COO(-)], and hydroxypropylmethylimidazolium glycolate [HOPMIM(+)][glycolate(-)] were found to be less toxic than conventional organic solvent such as chloroform or toluene, accoding the Microtox® toxicity assays. The toxicity of pyrrolidinium cation was lower than the imidazolium and pyridinium ones. It was found that the inclusion of an hydroxyl group in the alkyl chain length of the cation also reduce the toxicity of the ionic liquid. To sum up, the Microtox® toxicity assays can be used as screening tool to easily determined the toxicity of a wide range of ionic liquids and the toxicity data obtained could allow the obtention of structure-toxicity relationships to design less toxic ionic liquids.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP367522961	1-Butyl-1-methylpyrrolidinium trifluoromethanesulfonate		367522-96-1	Price