Effects of the Kynurenine 3-hydroxylase Inhibitor Ro 61-8048 After Intrastriatal Injections on the Severity of Dystonia in the Dt Sz Mutant

Melanie Hamann, Svenja E Sander, Angelika Richter

Eur J Pharmacol. 2008 May 31;586(1-3):156-9.

PMID: 18353306

Abstract:

Striatal dysfunctions seem to play a key role in the pathophysiology of dystonia in the dt(sz) mutant hamster, a model of paroxysmal non-kinesigenic dyskinesia, in which stress precipitates dystonic episodes. Previous examinations have shown changes in kynurenic acid levels and antidystonic effects of the kynurenine 3-hydroxylase inhibitor 3,4-dimethoxy-N-[4-(3-nitrophenyl)thiazol-2-yl]benzenesulfon-amide (Ro 61-8048) after systemic treatment in dt(sz) hamsters. In the present study, intrastriatal injections of Ro 61-8048 (60-80 microg/hemisphere) significantly reduced the severity of dystonia in dt(sz) hamsters, suggesting that kynurenine 3-hydroxylase inhibitors may be interesting candidates for managing dyskinesias which are related to striatal dysfunction.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP199666030	Ro 61-8048		199666-03-0	Price