Imidazole-based Small Molecules That Promote Neurogenesis in Pluripotent Cells

Gun-Hee Kim, Debasish Halder, Jinhong Park, Wan Namkung, Injae Shin

Angew Chem Int Ed Engl. 2014 Aug 25;53(35):9271-4.

PMID: 25044422

Abstract:

Reported herein are two imidazole-based small molecules, termed neurodazine (Nz) and neurodazole (Nzl), which induce neuronal differentiation of pluripotent P19 cells. Their ability to induce neurogenesis of P19 cells is comparable to that of retinoic acid. However, Nz and Nzl were found to be more selective neurogenesis inducers than retinoic acid owing to their unique ability to suppress astrocyte differentiation of P19 cells. Our results also show that Nz and Nzl promote production of physiologically active neurons because P19-cell-derived neurons induced by these substances have functional glutamate responsiveness. The present study suggests that Nz and Nzl could serve as important chemical tools to induce formation of specific populations of neuronal cell types from pluripotent cells.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP937807664-A	Neurodazine		937807-66-4	Price