In Vivo Activation of an omega-6 Oxygenase in Human Skin

A N Baer, P B Costello, F A Green

Biochem Biophys Res Commun. 1991 Oct 15;180(1):98-104.

PMID: 1930242

Abstract:

To test the hypothesis that an epidermal fatty acid oxygenase is activated in vivo under physiologic conditions, surface lipids from normal human skin were analyzed for oxygenase products. With high-performance liquid chromatography on reversed-phase and straight-phase chiral columns and gas-liquid chromatography/mass spectrometry, these lipids were found to contain free 13-hydroxyoctadeca-9Z,11E-dienoic acid and 9-hydroxyoctadeca-10E,12Z-dienoic acid. The 13-hydroxyoctadecadienoic acid was present as a stereoisomeric mixture, with an average S/R ratio of 2.2, and exceeded the concentration of 9-hydroxyoctadecadienoic acid by a factor of 2. These observations and others indicate that the 13-hydroxyoctadecadienoic acid was derived mostly from an omega-6 oxygenase (probably 15-lipoxygenase) which is activated in vivo in normal skin.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP29623287	13(S)-Hydroxyoctadeca-9Z,11E-dienoic acid		29623-28-7	Price