Inhibition of Endogenous Dopamine Release in Amphibian Retina by L-2-amino-4-phosphonobutyric Acid (L-AP4) and trans-2-aminocyclopentane-1,3-dicarboxylate (ACPD)

J H Boatright, J R Gordon, P M Iuvone

Brain Res. 1994 Jun 27;649(1-2):339-42.

PMID: 7525012

Abstract:

The metabotropic glutamate receptor agonists 2-amino-4-phosphonobutyric acid (AP4) and trans-2-aminocyclopentane-1,3-dicarboxylate (ACPD) blocked light-stimulated dopamine release from Xenopus laevis retina. ACPD suppressed release in darkness but AP4 did not. AP4 blocked release stimulated in darkness by picrotoxin, a GABA-A receptor antagonist. The data suggest that regulation of dopamine release in Xenopus retina involves subpopulations of metabotropic glutamate receptors.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP23052815-A	L-(+)-2-Amino-4-phosphonobutyric acid		23052-81-5	Price