Lanthanide-Doped SPIONs Bioconjugation With Trastuzumab for Potential Multimodal Anticancer Activity and Magnetic Hyperthermia

Weronika Gawęda, Magdalena Osial, Michał Żuk, Marek Pękała, Aleksander Bilewicz, Pawel Krysinski

Nanomaterials (Basel). 2020 Feb 8;10(2):288.

PMID: 32046284

Abstract:

Iron oxide-based nanoparticles have been modified in their core with holmium(III) in an amount affecting only slightly their magnetic properties. Nanoparticles were conjugated covalently with biomolecule of trastuzumab (Herceptin®), the monoclonal antibody that recognizes cancer cells overexpressing HER2 receptors targeting such nanoparticles to the specified tumor tissues. Systematic studies of Ho3+-doped bioconjugates were carried out as a preliminary step for future replacement of 'cold' Ho with 166Ho radionuclide, emitting 'soft' beta(-) radiation for possible targeted radionuclide therapy. Physicochemical properties of the obtained bioconjugates were subsequently tested for use in magnetic hyperthermia, considered as an effective, low-invasiveness anticancer therapy. With such a system we expect to achieve both: active targeting and multimodal action by simultaneous internal and localized irradiation and magnetic hyperthermia of specific cancers.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP12055628-A	Holmium(III) oxide		12055-62-8	Price