Phillyrin Is an Effective Inhibitor of Quorum Sensing With Potential as an anti-Pseudomonas Aeruginosa Infection Therapy

Shuxin Zhou, An Zhang, Weihua Chu

J Vet Med Sci. 2019 Mar 30;81(3):473-479.

PMID: 30686799

Abstract:

In the present study, we evaluated the antibacterial and anti-quorum sensing qualities of phillyrin. The minimum inhibitory concentration (MIC) of phillyrin with regard to Pseudomonas aeruginosa is 0.5 mg/ml. The production of virulence factors-such as rhamnolipid (>78.69%), pyocyanin (>85.94%), and elastase (>89.95%)-that affect the pathogenicity of the P. aeruginosa strain PAO1 apparently declined in the presence of 0.25 mg/ml phillyrin. Biofilm formation decreased by 84.48%. In a Caenorhabditis elegans-Pseudomonas aeruginosa infection model, diseased worms lived longer (63.33%) in a phillyrin-containing medium than in a drug-free medium, and the drug did not directly kill the pathogen. Therefore, the present work suggests that phillyrin has potential as an antimicrobial agent for the control of infectious pathogens.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP487412	Phillyrin		487-41-2	Price